Lanmodulin 工程化外膜囊泡用于协同靶向放射免疫治疗
Lanmodulin-Engineered Outer Membrane Vesicles for Synergistic Targeted Radio-Immunotherapy.
FRONTIER PAPERS
Lanmodulin-Engineered Outer Membrane Vesicles for Synergistic Targeted Radio-Immunotherapy.
PSMA-directed CAR-T cell therapy for metastatic castration-resistant prostate cancer: a next-generation engineering perspective on stem cell-derived i
Natural killer and CAR-NK cell therapies in urological cancers: Progress, mechanistic lessons from CAR-T, and future directions.
The establishment of polypeptide PSMA-targeted chimeric antigen receptor-engineered natural killer cells for castration-resistant prostate cancer and
p-PSMA-CAR-NK92MI 细胞可在体外和体内有效杀伤 CRPC PSMA+细胞。该策略可能为 CRPC 患者提供额外的治疗选择。
Combined treatment with anti-PSMA antibody and human peripheral blood-derived NK cells for castration-resistant prostate cancer.
抗 PSMA 抗体与人 PB-NK 细胞联合治疗可提高对 CRPC 的抗肿瘤疗效,是临床上治疗 CRPC 的一种有前景的方法。
A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity against Prostate Cancer.
Tumor epitope spreading by a novel multivalent therapeutic cellular vaccine targeting cancer antigens to invariant NKT-triggered dendritic cells in si
本研究的发现凸显了表达肿瘤抗原的 aAVCs 在诱导高效表位扩展和产生针对癌症的强效免疫应答方面具有前景广阔的作用。我们的结果还表明,表达多价抗原的 aAVCs 是一种有前景的治疗选择,可能成为治疗前列腺癌等冷肿瘤的更全面的疗法。
Comparative analysis of second and third-generation nanobody-based CAR-NK cells targeting PSMA in prostate cancer immunotherapy: In silico and in vitr
根据计算研究,NB/Flag/hinge 主要通过静电作用力与 PSMA 相互作用。更重要的是,靶向 PSMA 的第三代 CAR NK 细胞相对于第二代 CAR NK 细胞表现出增强的细胞毒性和细胞因子产生,表明其具有更大的治疗应用潜力。
MICA/MICB-Mediated NKG2D Immune Escape in Cervical Cancer: Single-Cell Transcriptomic Mapping of Radionuclide Therapy Targets for Precision Radioimmun
Hemoglobin-Based Oxygen Carriers Promoted the Antitumor Effect of (177)Lu-PSMA-617 by Enhancing DNA Repair Capacity of Immune Cells.
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