下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
FRONTIER PAPERS
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
Advances in CAR-T therapy for central nervous system tumors.
CAR-T 细胞疗法在中枢神经系统肿瘤中的应用已取得显著进展;
The PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial.
主要终点为 tebotelimab 单药给药(n = 269)或与抗 HER2 抗体 margetuximab 联合给药(n = 84)时的安全性和最大耐受剂量。
A CD19-Anti-ErbB2 scFv Engager Protein Enables CD19-Specific CAR T Cells to Eradicate ErbB2(+) Solid Cancer.
CD19特异性CAR T细胞治疗白血病/淋巴瘤的疗效,至少部分依赖于特定CAR的独特性质以及健康B细胞的存在,后者通过反复刺激增强靶细胞裂解和细胞因子分泌。
Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment.
使用嵌合抗原受体(CAR)T 细胞治疗 B 细胞淋巴瘤和白血病已取得显著成功。
Full-length recombinant antibodies from Escherichia coli: production, characterization, effector function (Fc) engineering, and clinical evaluation.
尽管在大肠杆菌中生产的几种抗体片段和抗体片段融合蛋白已被证明是安全有效的治疗药物,但产量低和易形成包涵体仍然是限制其广泛应用的主要障碍。
Associations between BCL-2 expression and different histopathological prognostic factors in different molecular subtypes of invasive breast carcinoma
BCL-2在IBC中的表达;NST根据癌症分子亚型的不同具有不同的预后影响。在HER2富集表型的癌症中,BCL-2表达是不良预后的标志物,而在激素受体阳性表型的癌症中,BCL-2表达具有较好的预后影响。
CD28 and 41BB Costimulatory Domains Alone or in Combination Differentially Influence Cell Surface Dynamics and Organization of Chimeric Antigen Recept
我们得出结论,CAR的分子结构、膜组织和流动性是关键的设计参数,能够预测有效免疫突触的形成。
Engineering Human MAIT Cells with Chimeric Antigen Receptors for Cancer Immunotherapy.
用嵌合Ag受体(CAR)工程化免疫细胞是癌症免疫治疗中一项有前景的技术。
Cardiac Toxicity Associated with Cancer Immunotherapy and Biological Drugs.
肿瘤免疫治疗对改善肿瘤患者的预后有显著贡献。
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