CELL INTELLIGENCE · 肿瘤细胞治疗研究

开发基于溶瘤病毒递送 CD19 和 EGFRvIII 抗原与双特异性 CAR 的胶质母细胞瘤多模式治疗

Developing a multimodal therapy for glioblastoma using oncolytic virus delivering CD19 and EGFRvIII antigens and bi-specific CARs.

Axicabtagene ciloleucel 联合利妥昔单抗治疗难治性大 B 细胞淋巴瘤：2 期单臂 ZUMA-14 试验

Axicabtagene ciloleucel in combination with rituximab for refractory large B cell lymphoma: the phase 2, single-arm ZUMA-14 trial.

活细胞 Pick-Seq（LiP-Seq）：探究 CAR-T19 治疗后的超罕见套细胞淋巴瘤持续细胞

Live-cell Pick-Seq (LiP-Seq): Interrogating ultra-rare mantle cell lymphoma persistent cells after CART19 therapy.

自适应制备慢病毒抗 CD20/抗 CD19 CAR-T 细胞治疗复发/难治性套细胞淋巴瘤的 I/II 期研究

Phase I/II Study of Adaptive Manufactured Lentiviral Anti-CD20/Anti-CD19 Chimeric Antigen Receptor T Cells for Relapsed, Refractory Mantle Cell Lympho

我们证明，现场适应性生产的 LV20.19 CAR-T 细胞用于复发/难治性 MCL 是可行、安全且有效的，最佳 ORR 为 100%，安全性特征良好，迄今复发很少。

NKTR-255 联合 CD19-22 CAR-T 细胞疗法治疗难治性 B 细胞急性淋巴细胞白血病的 1 期临床试验

A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia.

用于治疗复发/难治性非霍奇金淋巴瘤的初始/记忆 T 细胞中 CD19/CD20 双特异性嵌合抗原受体 (CAR)

CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma.

CAR-T 细胞的剂量-反应相关性：临床研究的系统评价

Dose-response correlation for CAR-T cells: a systematic review of clinical studies.

多特异性 CAR-T 细胞使淋巴瘤无法通过抗原丢失逃逸

Multispecific CAR T Cells Deprive Lymphomas of Escape via Antigen Loss.

抗原结合与信号传导受损干扰双特异性 CD19 和 CD79a 嵌合抗原受体功能

Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function.

接受双特异性 LV20.19 CAR-T 细胞治疗患者的长期结局及早期缓解、晚期复发与生存的预测因素

Long-term outcomes and predictors of early response, late relapse, and survival for patients treated with bispecific LV20.19 CAR T-cells.