CELL INTELLIGENCE · 肿瘤细胞治疗研究

下一代基于抗体的癌症治疗：抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用

Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors

构建一种高度通用、经优化的 TCR 双特异性支架，用于靶向肿瘤特异性肽-HLA 抗原

Generation of a highly versatile TCR bispecific scaffold optimized for targeting tumor-specific peptide-HLA antigens.

超越免疫检查点阻断：T 细胞衔接器与抗体药物偶联物在癌症与自身免疫性疾病中的应用

Beyond immune checkpoint blockade: T cell engagers and antibody-drug conjugates in cancer and autoimmune disease.

使用溶瘤病毒将 T 细胞衔接器重定向以靶向实体瘤的通用即用型联合免疫疗法

Universal off-the-shelf combination immunotherapy using oncolytic viruses to redirect T cell engagers to target solid tumors.

我们的研究结果表明，OV 与 TCEs 的联合提供了一种有前景的策略，可驱动针对实体瘤的抗肿瘤免疫应答。该方法代表了一种新颖且通用的平台，目前正处于将 TCE 疗法与溶瘤病毒疗法联合的 1 期临床试验中，克服了抗原异质性和免疫屏障，从而实现实体瘤的有效治疗。

靶向 BCMA 和 CD19 的双特异性 CAR-T 细胞治疗复发/难治性多发性骨髓瘤：I/II 期试验

Bispecific CAR T cell therapy targeting BCMA and CD19 in relapsed/refractory multiple myeloma: a phase I/II trial.

多发性骨髓瘤的双特异性抗体和双靶向 CAR-T 细胞：2023 ASCO 年会最新进展

Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting.

用于血液系统恶性肿瘤免疫治疗的双特异性和三特异性免疫细胞衔接器

Bi- and trispecific immune cell engagers for immunotherapy of hematological malignancies.

CAR-T 细胞的剂量-反应相关性：临床研究的系统评价

Dose-response correlation for CAR-T cells: a systematic review of clinical studies.

肾脏病学趋势：从虚无主义到抗体介导排斥反应的靶向治疗

Trends in Nephrology: From nihilism to targeted treatment of antibody-mediated rejection.

多发性骨髓瘤中的单特异性和双特异性嵌合抗原受体（CAR）T 细胞治疗：系统综述、荟萃分析与荟萃回归

Monospecific and Bispecific Chimeric Antigen Receptor (CAR) T-cell Therapy in Multiple Myeloma: A Systematic Review, Meta-analysis and Meta-regression