CELL INTELLIGENCE · 肿瘤细胞治疗研究

SLC7A11 与 PD-L1 共表达增高与结外自然杀伤 T 细胞淋巴瘤患者不良预后相关

The increased co-expression of SLC7A11 and PD-L1 was associated with poor prognosis in extranodal natural killer T-cell lymphoma patients.

GPC3 嵌合抗原受体 (CAR)-NK 细胞联合 Enoblituzumab 增强抗肝细胞癌疗效

GPC3 chimeric antigen receptor (CAR)-NK cells combined with Enoblituzumab enhance the anti-tumor efficacy against hepatocellular carcinoma.

PD-1 与 NKG2A 双重阻断预防 NK 细胞衰老并重编程胰腺癌免疫抑制微环境

Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer.

增强 PD-L1 靶向提升 FOLR1- CAR NK92 细胞对卵巢癌的杀伤活性

Enhanced PD-L1 targeting boosts the cytotoxic activity of FOLR1- CAR NK92 cells against ovarian cancer.

双靶向仿生纳米平台在乳腺癌中根除致癌细菌并重振抗肿瘤免疫

Dual Targeting Biomimetic Nanoplatform Eradicates Oncogenic Bacteria While Reinvigorating Anti-Tumor Immunity in Breast Cancer.

双靶向 MUC-1 和 PD-L1 的 CAR-NK92MI 联合免疫治疗用于复发/难治性实体瘤患者的 I 期试验：聚焦非小细胞肺癌

A phase I trial of combination CAR-NK92MI immunotherapy by dual targeting MUC-1 and PD-L1 for patients with relapsed or refractory solid tumors: focus

我们的结果表明，MUC-1 与 PD-L1 联合靶向的 CAR-NK92MI 细胞疗法是治疗伴转移的复发/难治性非小细胞肺癌患者的安全有效方法。

双重靶向 OX40 和 IL-2 受体通过清除肿瘤浸润 Treg 与促进 CD8(+) T 细胞增殖增强抗肿瘤活性

Dual targeting OX40 and IL-2 receptor enhances antitumor activity through tumor-infiltrating Treg depletion and CD8(+) T-cell proliferation.

我们的研究揭示了一种新的 IL-2 设计方法，可解决现有策略的若干关键缺陷，并阐明了 aOX40-mIL2-Fc 疗法的细胞机制。

肿瘤相关细菌激活 PRDX1 驱动的糖酵解以促进肝细胞癌的免疫逃逸和 PD-1 抗体耐药

Tumor-associated bacteria activate PRDX1-driven glycolysis to promote immune evasion and PD-1 antibody resistance in hepatocellular carcinoma.

我们的研究结果确定了 PRDX1 是细菌驱动的代谢重编程中的核心节点，该重编程促进了 HCC 中的免疫逃逸和对 PD-1 治疗的耐药性。这些发现首次提供了将瘤内细菌通过氧化还原调控的代谢与 PD-1 耐药性联系起来的证据，提出将 PRDX1 和肠道微生物群双重靶向作为一种新的联合免疫治疗策略。

共同阻断 TIGIT 和 PVRIG 的新型双特异性抗体增强抗肿瘤免疫

Co-blocking TIGIT and PVRIG Using a Novel Bispecific Antibody Enhances Antitumor Immunity.

Aurora-A 和 Bcl-xL 的双重靶向协同重塑乳腺癌免疫微环境并诱导细胞凋亡

Dual Targeting of Aurora-A and Bcl-xL Synergistically Reshapes the Immune Microenvironment and Induces Apoptosis in Breast Cancer.