CELL INTELLIGENCE · 肿瘤细胞治疗研究

微流控 Cytotongue 系统实现肿瘤球体中 CAR-T 诱导机械软化的早期无标记检测

Microfluidic Cytotongue system enables early, label-free detection of CAR-T-induced mechanical softening in tumor spheroids.

一种肿瘤靶向七甲川花菁染料通过诱导致死性自噬抑制三阴性乳腺癌

A tumor-targeted heptamethine cyanine dye suppresses triple-negative breast cancer by induction of lethal autophagy.

本研究介绍了一种可能有效增强 TNBC 治疗效果的策略。

聚焦超声触发的多柔比星脂质体重塑肿瘤微环境以增强三阴性乳腺癌模型中的检查点耗竭

Focused ultrasound-triggered doxorubicin liposomes reshape tumor microenvironment to boost checkpoint depletion in triple-negative breast cancer model

前瞻性 MIRINAE 试验（辅助阿替利珠单抗联合卡培他滨对比卡培他滨的随机 II 期试验；KCSG-BR18-21）中新辅助化疗后残留浸润性三阴性乳腺癌的基因组与转录组分析

Genomic and transcriptomic analyses of residual invasive triple-negative breast cancer after neoadjuvant chemotherapy in the prospective MIRINAE trial

标准 NAC 后残留的 TNBC 主要为基底样或 MES/BLIS 亚型，并具有可变的肿瘤微环境（TME）。

抗体片段介导的原位肿瘤表面修饰用于抗原非依赖性通用型肿瘤免疫治疗

In Situ Tumor Surface Modification with Antibody Fragments for Antigen-Independent Versatile Cancer Immunotherapy.

两亲性脂质-单链 DNA 偶联物介导的细胞表面工程用于可编程细胞间连接和免疫突触形成

Amphiphilic Lipid-Single-Stranded DNA Conjugate-Mediated Cell Surface Engineering for Programmable Intercellular Tethering and Immune Synapse Formatio

用于乳腺癌模型精准免疫治疗的优化细菌递送方法

Optimized bacterial delivery approaches for precision immunotherapy in breast cancer models.

定制可识别肿瘤的透明质酸-脂质偶联物以增强表面工程化 NK 细胞的抗癌疗效

Tailoring tumor-recognizable hyaluronic acid-lipid conjugates to enhance anticancer efficacies of surface-engineered natural killer cells.

ELK3 通过调控线粒体动力学调节 NK 细胞对三阴性乳腺癌的抗肿瘤疗效

ELK3 modulates the antitumor efficacy of natural killer cells against triple negative breast cancer by regulating mitochondrial dynamics.

这些数据提示，NK 细胞对 TNBC 的应答与 ELK3 表达水平直接相关，为改进基于 NK 细胞的 TNBC 免疫治疗疗效的策略提供了新见解。

乳腺癌幸存者的非霍奇金淋巴瘤风险：一项全国性队列研究

Risk of non-Hodgkin lymphoma in breast cancer survivors: a nationwide cohort study.