辐照 CD19 嵌合抗原受体 YTS 细胞保留抗肿瘤活性并可作为自体 CAR-T 疗法的可规模化替代方案
Irradiated CD19 chimeric antigen receptor YTS cells retain antitumor activity and offer a scalable alternative to autologous CAR-T therapy.
嵌合抗原受体(CAR)T 细胞疗法彻底改变了淋巴瘤和多发性骨髓瘤等血液系统恶性肿瘤的治疗。
FRONTIER PAPERS
Irradiated CD19 chimeric antigen receptor YTS cells retain antitumor activity and offer a scalable alternative to autologous CAR-T therapy.
嵌合抗原受体(CAR)T 细胞疗法彻底改变了淋巴瘤和多发性骨髓瘤等血液系统恶性肿瘤的治疗。
Outcomes of loncastuximab tesirine in heavily pretreated patients with diffuse large B-cell lymphoma, including the post-CAR T-cell therapy setting: A
Loncastuximab tesirine 在经重度治疗的 R/R DLBCL 中显示出具有临床意义的活性,包括 CAR-T 细胞治疗后的情形,血细胞减少常见但可控。汇总估计显示存在显著异质性,主要由真实世界队列驱动,应谨慎解读。
CAR-engineered cell therapies: current understandings and future perspectives.
嵌合抗原受体(CAR)工程化细胞疗法是免疫治疗领域的重大突破,最初应用于癌症,如今正拓展至多个临床领域。
Distinct Cellular and Molecular Patterns in Pretreatment Peripheral Blood Are Associated with CAR T-cell Outcomes in Diffuse Large B-cell Lymphoma.
尽管其取得了成功,但仍有约 60% 的患者治疗失败,这凸显出有必要更好地理解应答与耐药的决定因素。
Bendamustine-based lymphodepletion prior to CAR T-cell therapy: a systematic review.
共纳入 18 项研究,涵盖 1400 余例患者。
Targeting PRC2 Enhances the Cytotoxic Capacity of Anti-CD19 CAR T Cells against Hematologic Malignancies.
我们的结果表明,靶向 PRC2 可能是增强 CAR T 细胞针对血液系统恶性肿瘤的功能性效应程序的一种有前景的方法。
Durable response to CAR T is associated with elevated activation and clonotypic expansion of the cytotoxic native T cell repertoire.
虽然嵌合抗原受体(CAR)T 细胞疗法可使复发性大 B 细胞淋巴瘤获得持久缓解,但持续性有限,长期应答的机制尚未完全阐明。
Advances and challenges in CAR-T cell therapy for head and neck squamous cell carcinoma.
头颈部鳞状细胞癌(HNSCC)仍是最具侵袭性的恶性肿瘤之一,治疗选择有限,尤其是在复发和转移性病例中。
Improved survival and health care use with CAR-T vs historical care in relapsed/refractory large B-cell lymphoma.
抗CD19 CAR-T细胞免疫疗法自2019年底起在加拿大获得资助,用于治疗复发/难治性大B细胞淋巴瘤(R/R-LBCL)且接受过至少两线全身治疗后的患者。
Viral Reactivation in Multiple Myeloma Patients Receiving Anti-BCMA Chimeric Antigen Receptor T-Cell Therapy.
这些发现表明,尽管CMV和EBV再激活在抗BCMA CAR-T后相对常见,但它们很少与有意义的疾病相关,且其风险不超过CD19靶向治疗的风险。
MEMBER ACCOUNT
登录成功会直接打开下一页。