肿瘤细胞治疗研究
FRONTIER PAPERS
Anti-CD123 CAR-T therapy combined with autologous SCT and venetoclax maintenance in refractory BPDCN ineligible for allogeneic transplantation: a case
患者获得了持续的 MRD 阴性 CR，无病生存期超过 13 个月。
Mechanical Properties Measured by Atomic Force Microscopy Help Evaluate Different Constructions of Re-engineered Chimeric Antigen Receptor-T Models.
尽管嵌合抗原受体-T（CAR-T）在血液系统恶性肿瘤中取得成功，但挑战依然存在，包括在实体瘤中疗效有限、on-off 肿瘤毒性以及 CAR-T 细胞持久性。
Breakthroughs of CAR T-cell therapy in acute myeloid leukemia: updates from ASH 2024.
尽管嵌合抗原受体（CAR）T 细胞疗法已经彻底改变了淋巴系统恶性肿瘤的治疗格局，但其最大的挑战仍在于急性髓系白血病（AML）的治疗。
To BE or to PE: Prime editors provide more choices for epitope-editing-based immunotherapy.
表位编辑是一种有前景的策略，可保护造血细胞免受免疫治疗的清除。
BRD4 inhibitor reduces exhaustion and blocks terminal differentiation in CAR-T cells by modulating BATF and EGR1.
我们的研究显示，BRD4 抑制剂可通过下调 BATF 的活性与表达并上调 EGR1 的活性与表达，减少 CAR-T 细胞耗竭并阻断耗竭 T 细胞的终末分化。
Epitope prime editing shields hematopoietic cells from CD123 immunotherapy for acute myeloid leukemia.
为提高精确性，我们优化了先导编辑，使 HSPCs 中的编辑效率从 5.9% 提升至 78.9%。
Novel CD123×CD33 bicistronic chimeric antigen receptor (CAR)-T therapy has potential to reduce escape from single-target CAR-T with no more hematotoxi
Valproic acid increases CAR T cell cytotoxicity against acute myeloid leukemia.
CD123和CLL-1是AML CAR-T细胞治疗的有前景的靶点。
BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia.
程序性细胞死亡受体-1（PD-1）的持续表达与T细胞耗竭相关，而阻断PD-1通路是治疗多种癌症的有效免疫治疗策略。
Early intrathecal dexamethasone and methotrexate as an effective approach for immune effector cell-associated neurotoxicity syndrome after CAR-T cell
我们的数据提示，早期给予 IDM 可能有助于快速缓解 CAR-T 细胞治疗后的重度或类固醇难治性 ICANS，这可能为这些患者的后续治疗创造机会。
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