肿瘤细胞治疗研究
FRONTIER PAPERS
Emerging therapeutic advances for immune thrombocytopenia: highlights from selected early‑phase and pivotal trials at the 2025 ASH annual meeting.
本通讯重点介绍了 2025 ASH 年会上报告的免疫性血小板减少症 (ITP) 新兴免疫靶向疗法。
LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells.
根据这些结果，LLT1 过表达增强了 UCAR-T 细胞的活性并防止同种异体排斥反应，为通用型 CAR-T 细胞疗法的开发提供了重要见解。
Relapsed/refractory multiple myeloma with extramedullary plasmacytomas successfully rechallenged with humanized B-cell maturation antigen-directed chi
这些发现支持进一步研究再治疗策略和CAR-T后维持治疗方法。
CD38-Specific CAR Integrated into CD38 Locus Driven by Different Promoters Causes Distinct Antitumor Activities of T and NK Cells.
这些结果支持了 CD38 CAR-T/NK 对 T-ALL 的疗效，并证明“二合一”策略能够解决自相残杀问题并增强肿瘤清除，为临床转化铺平了道路。
Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myelom
我们比较了BCMA CAR-T治疗前和BCMA CAR-T治疗后复发时CD45 + BM细胞的异质性。
All-trans retinoic acid improves NSD2-mediated RARα phase separation and efficacy of anti-CD38 CAR T-cell therapy in multiple myeloma.
本研究阐明了 ATRA 调控 CD38 表达的一种机制，并拓展了 ATRA 在改善多发性骨髓瘤患者抗 CD38 免疫治疗方面的临床潜力。Cite Now.
High efficacy and safety of CD38 and BCMA bispecific CAR-T in relapsed or refractory multiple myeloma.
我们的结果证实，BCMA-CD38 CAR-T细胞疗法治疗R/R MM患者是可行的，具有高缓解率、低复发率和可控的CRS，将成为R/R MM一种有前景的治疗选择。
A bispecific CAR-T cell therapy targeting BCMA and CD38 in relapsed or refractory multiple myeloma.
双特异性BM38 CAR-T在RRMM患者中可行、安全且显著有效。
Strategic innovations: Tackling challenges of immunotherapy in acute myeloid leukemia.
这些方法共同旨在为改善 AML 的免疫治疗结局提供新的见解。
Structural dissection of CD38 antigen engagement by CAR binders and rational affinity tuning.
嵌合抗原受体（CAR）T 细胞疗法利用合成受体引导 T 细胞靶向并裂解癌细胞。
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