CELL INTELLIGENCE · 肿瘤细胞治疗研究

自协同 RNA 疫苗减轻树突状细胞介导的获得性免疫抵抗以增强细胞疗法对实体瘤的疗效

Self-Cooperative RNA Vaccine Mitigates Dendritic Cell-Mediated Acquired Immune Resistance to Potentiate Cell Therapy for Solid Tumors.

通过双功能 RNA 调控系统增强 MHC-I 类抗原呈递以逆转肿瘤免疫逃逸

Reversal of tumour immune evasion via enhanced MHC-Class-I antigen presentation by a dual-functional RNA regulated system.

本研究成功构建了一种双功能 RNA 调控系统，该系统可增强肿瘤细胞抗原呈递并重塑 TME 内的免疫格局，从而增强 mRNA 疫苗的抗肿瘤疗效。