实体瘤的免疫细胞治疗:当前挑战与治疗进展
Immune cell-based therapies for solid tumors, current challenges and therapeutic advances.
实体瘤仍难以治疗,原因在于抗原异质性、限制免疫细胞迁移的物理屏障以及深度免疫抑制的肿瘤微环境(TME)。
FRONTIER PAPERS
Immune cell-based therapies for solid tumors, current challenges and therapeutic advances.
实体瘤仍难以治疗,原因在于抗原异质性、限制免疫细胞迁移的物理屏障以及深度免疫抑制的肿瘤微环境(TME)。
Anti-PD-1 single-chain variable fragments in cancer immunotherapy: from molecular engineering to clinical translation.
程序性死亡-1(PD-1)免疫检查点是癌症中T细胞耗竭和免疫逃逸的核心调节因子。
Engineered immune cell therapies for solid tumors: pharmacological advances, clinical outcomes, and future directions.
实体肿瘤约占人类癌症的90%,由于抗原异质性、免疫抑制微环境以及常规药物治疗的可及性有限,其治疗面临独特挑战。
Novel strategies in breast cancer management: From treatment to long-term remission.
乳腺癌(BC)是女性中最常见的恶性肿瘤,也是全球癌症相关死亡的主要原因之一。
Current landscape and future prospects of interleukin-2 receptor (IL-2R) agonists in cancer immunotherapy.
然而,不到50%的患者从ICB中获益,这凸显了对更有效免疫治疗选择的需求。
Next-generation immune cell therapies for lung cancer: advances in CAR-T, NK, and TIL strategies.
这些下一代免疫细胞疗法代表了一种快速发展和具有转化相关性的方法,可能扩大治疗选择、改善生存,并在已耗尽常规疗法的肺癌患者中提供持久的抗肿瘤反应。
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