CELL INTELLIGENCE · 肿瘤细胞治疗研究

同基因小鼠模型中 7 × 19 CAR-T 细胞给药诱导的受者免疫细胞基因表达谱分析

Gene expression profiling of recipient immune cells induced by 7 × 19 CAR-T cell dosing in a syngeneic mouse model.

表达 IL-7/CCL19 的 CAR-T 细胞短期制备增强并延长实体瘤模型中的疗效

Short-term manufacturing of IL-7/CCL19-expressing CAR-T cells enhances and prolongs therapeutic effects in solid tumor models.

IL-15 与 IL-21 协同作用提高 iPSC 来源的细胞毒性 T 细胞在实体瘤中的抗肿瘤疗效

IL-15 and IL-21 synergy improves anti-tumor efficacy of iPSC-derived cytotoxic T cells in solid tumors.

组成性 STAT3 信号与 STAT5 相比增强 CAR-T 细胞疗效并降低全身毒性

Constitutive STAT3 Signaling, in Comparison with STAT5, Enhances CAR T-cell Efficacy and Lowers Systemic Toxicity.

溶瘤病毒联合 CAR-T 细胞治疗重振实体瘤中的肿瘤-免疫循环

Reinvigorating the Cancer-Immunity Cycle With Combined Oncolytic Virus and CAR-T Cell Therapies in Solid Tumors.

通过生成 CAR 序列微调蛋白质语言模型增强 CAR-T 细胞活性预测

Enhancing CAR-T cell activity prediction via fine-tuning protein language models with generated CAR sequences.

我们的发现凸显了将序列增强与 PLMs 微调相结合以推进数据驱动的 CAR-T 细胞设计的潜力。

共表达 IL-7 与 CCL19 的 CAR-T 细胞促进表位扩展以增强抗肿瘤免疫

CAR-T cells co-expressing IL-7 and CCL19 promote epitope spreading to enhance antitumor immunity.

通过 LNP 介导的 CAR-mRNA 递送靶向实体瘤中的成纤维细胞激活蛋白促进小鼠模型中的持久消退

Targeting fibroblast activation protein in solid tumors via LNP-mediated CAR-mRNA delivery promotes durable regression in murine models.

嵌合 PD-1 受体重定向原代 T 细胞靶向儿童实体瘤，但不作用于 PD-1 配体阳性且共表达 CD80 的细胞

Chimeric PD‑1 receptor redirects primary T cells against childhood solid tumors but not to PD‑1 ligand‑positive CD80‑coexpressing cells.

分泌 Relaxin-2 的 CAR-T 细胞在富含基质异种移植瘤中显示增强疗效

Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors.

RLN2 可能通过促进 CAR-T 细胞浸润到肿瘤微环境，增强其对抗实体瘤的抗肿瘤活性。