印度 CAR-T 细胞生产过程中基因组重编程的真实世界见解
Real-world insights into genomic reprogramming during CAR-T cell manufacturing in India.
本土 CAR-T 制造过程诱导显著的转录组重塑,并反映出与改善的功能适应性相关的高增殖和细胞因子反应性 CAR-T 表型。这些发现可能为真实世界临床环境中探索结局相关分析的 CAR-T 基因组特征描述提供基线框架。
肿瘤细胞治疗研究
FRONTIER PAPERS
近 5 年肿瘤细胞治疗领域的研究论文。默认按评分排序(权威性 + 新鲜度)。
Real-world insights into genomic reprogramming during CAR-T cell manufacturing in India.
本土 CAR-T 制造过程诱导显著的转录组重塑,并反映出与改善的功能适应性相关的高增殖和细胞因子反应性 CAR-T 表型。这些发现可能为真实世界临床环境中探索结局相关分析的 CAR-T 基因组特征描述提供基线框架。
Umbilical cord blood-derived CAR-NK cells: an emerging off-the-shelf platform for cancer immunotherapy.
Clinical Pharmacology of Lisocabtagene Maraleucel in B-cell Malignancies.
A universally applicable toolbox for single-molecule quantification of chimeric antigen receptors using linker-resolved dSTORM microscopy.
From monoclonal to polyfunctional immunotherapy: Reprogramming CAR-T-cell therapy with oncolytic viruses in B-cell malignancies.
Evidence for early, clinically silent medial temporal lobe inflammation after CAR-T cell therapy.
这些数据提示 MTL 存在早期、临床沉默的炎症反应,可能对长期认知功能产生影响,尚需进一步研究。
Human single domain antibody-based CAR-T cells targeting BAFF-R demonstrate promising preclinical activity in B-cell malignancies.
我们开发了一种基于全人源单域抗体构建的新型 BAFF-R CAR-T 细胞产品。
Allogeneic CAR-T cell therapies: Overcoming clinical challenges and therapeutic potential against tumors.
Perspective for CAR T-Cell Therapy in Underrepresented Populations: A Hypothesis-Generating CD19 Genomic Analysis.
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