CELL INTELLIGENCE · 肿瘤细胞治疗研究

靶向 PD-L1 和 ErbB2（HER2）的双重 CAR-NK 细胞表现出协同 CAR 信号传导并抵抗实体瘤异质性

Dual CAR-NK cells targeting PD-L1 and ErbB2 (HER2) exhibit cooperative CAR signaling and counteract solid tumor heterogeneity.

同时靶向 PD-L1 与 ErbB2 可通过对抗原异质性提供抵抗力并经协同激活放大抗肿瘤信号，增强 CAR-NK 细胞对难治性实体瘤的疗效。

三阴性乳腺癌免疫治疗的进展与展望

Progress and Prospect of Immunotherapy for Triple-Negative Breast Cancer.

TNBC仅占新发乳腺癌诊断的约15%-20%；