CELL INTELLIGENCE · 肿瘤细胞治疗研究

展示双特异性 T 细胞衔接器的工程化细胞外囊泡用于 B 细胞恶性肿瘤的靶向治疗

Engineered extracellular vesicles displaying bi-specific T-cell engagers for targeted therapy of B-cell malignancies.

CAR-T 细胞治疗后免疫效应细胞相关神经毒性综合征：最新进展综述

Immune effector cell-associated neurotoxicity syndrome following CAR T-cell therapy: a review of recent advances.

ICANS 的管理正转向精准医学模式。

通过内吞途径切换和干扰素反应抑制增强工程化细胞外囊泡的抗肿瘤效应

Enhancing Anti-Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression.

通过利用 CAR 靶点修饰的细胞外囊泡的靶向细胞因子递送系统改善 CAR-T 细胞功能

Improving CAR-T cell function through a targeted cytokine delivery system utilizing car target-modified extracellular vesicles.

聚焦外泌体以突破 CAR-T 细胞治疗的现有瓶颈

Focusing on exosomes to overcome the existing bottlenecks of CAR-T cell therapy.

肿瘤来源外泌体通过外泌体 CD19 抗原诱导初始活化，但经 TGF-β 信号通路损害 CD19 特异性 CAR-T 细胞功能

Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling.

表达 CD19 抗原的细胞外囊泡改善 CD19 靶向 CAR-T 细胞的扩增与疗效

Extracellular Vesicles Expressing CD19 Antigen Improve Expansion and Efficacy of CD19-Targeted CAR-T Cells.

我们的研究结果表明，表达抗原的 EV 可作为增强剂，在体外和体内提高 CAR-T 细胞的疗效。

唇腺间充质干细胞来源外泌体介导的 miRNA-125b 通过靶向 PRDM1 并抑制浆细胞减轻实验性干燥综合征

Labial Gland Mesenchymal Stem Cell Derived Exosomes-Mediated miRNA-125b Attenuates Experimental Sjogren's Syndrome by Targeting PRDM1 and Suppressing

肿瘤来源细胞外囊泡诱导 CD19 CAR-T 细胞无效细胞因子释放与耗竭

Tumor-derived extracellular vesicles induce invalid cytokine release and exhaustion of CD19 CAR-T Cells.