肾脏病学趋势:从虚无主义到抗体介导排斥反应的靶向治疗
Trends in Nephrology: From nihilism to targeted treatment of antibody-mediated rejection.
FRONTIER PAPERS
Trends in Nephrology: From nihilism to targeted treatment of antibody-mediated rejection.
Monospecific and Bispecific Chimeric Antigen Receptor (CAR) T-cell Therapy in Multiple Myeloma: A Systematic Review, Meta-analysis and Meta-regression
Translating B-Cell and Plasma-Cell Targeting from Oncology to Autoimmunity: Modalities, Quantitative Bridging, and a Development Roadmap.
Comparative efficacy and safety of BCMA-targeted CAR T cells and BiTEs in relapsed/refractory multiple myeloma: a meta-analysis of interventional and
Unveiling causal immune cell-gene associations in multiple myeloma: insights from systematic reviews and Mendelian randomization analyses.
我们的研究支持 CAR-T 细胞疗法在 rrMM 患者中的疗效和安全性,ORR 为 82.2%,严重 CRS(6.3%)和神经毒性(0.9%)发生率低。这一发现还提示 BCMA/CD19 双特异性 CAR-T 细胞具有更优的 ORR,尚待临床确认。MR 分析揭示了免疫细胞、VDR 和 VHL 等基因与 MM 之间的关联,增进了我们对其病理生理学的理解。
Cellular therapy for multiple myeloma: what's now and what's next.
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