CELL INTELLIGENCE · 肿瘤细胞治疗研究

通过整合分子动力学和流式细胞术分析重新审视 CD20 上的 Ofatumumab 表位

Revisiting the Ofatumumab Epitope on CD20 through Integrative Molecular Dynamics and Flow Cytometry Analyses.

猪尾猕猴中的混合 CAR-T 筛选鉴定出具有增强增殖、迁移和持久性的设计

Pooled CAR-T screening in pig-tailed macaques identifies designs with enhanced proliferation, trafficking, and persistence.

基于内含肽的模块化嵌合抗原受体平台用于特异性 CD19/CD20 共靶向

Intein-based modular chimeric antigen receptor platform for specific CD19/CD20 co-targeting.

利用展示多结构域融合配体的慢病毒载体在非人灵长类体内生成 CAR-T 细胞

In vivo CAR T-cell generation in nonhuman primates using lentiviral vectors displaying a multidomain fusion ligand.

使用基于 Quantum pBac 的 CAR-T 工程系统制备 CD20/CD19 靶向 iCasp9 可调控 CAR-TSCM 细胞

Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using a Quantum pBac-based CAR-T engineering system.

B 细胞缺陷促进肺癌的发生与进展

B cell deficiency promotes the initiation and progression of lung cancer.

CD20 与 CD19 双特异性靶向提高 B 细胞恶性肿瘤中 CAR-T 细胞产品的多功能性

Bispecific targeting of CD20 and CD19 increases polyfunctionality of chimeric antigen receptor T-cell products in B-cell malignancies.

使用 CD19 或 CD20 抗原刺激均导致相似水平的分析物激活，提示该产品可能在 CD19- 患者群体中具有疗效。

CAR-T 细胞进入肿瘤岛是依赖 IFNγ 和 ICAM-1 的两步过程

CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1.

T 细胞，尤其是活化的 CD4⁺ 细胞，维持抗 CD20 介导的 NK 细胞活力与抗体依赖性细胞毒作用

T cells, particularly activated CD4(+) cells, maintain anti-CD20-mediated NK cell viability and antibody dependent cellular cytotoxicity.