CELL INTELLIGENCE · 肿瘤细胞治疗研究

CpG 1018 通过增强 CD8+ T 细胞反应来增强 mRNA 疫苗诱导的抗肿瘤免疫

CpG 1018 augments mRNA vaccine-induced anti-tumor immunity by potentiating CD8+ T cell responses.

晚期转移性黑色素瘤治疗新标准：免疫治疗与 BRAF 靶向治疗作为新兴范式

New Standards in the Treatment of Advanced Metastatic Melanoma: Immunotherapy and BRAF-Targeted Therapies as Emerging Paradigms.

泛素特异性蛋白酶 6 mRNA 脂质纳米颗粒在尤文肉瘤中激发抗肿瘤免疫并抑制肿瘤发生

Ubiquitin-Specific Protease 6 mRNA Lipid Nanoparticles Ignite Antitumor Immunity and Suppress Tumorigenesis in Ewing Sarcoma.

通过双功能 RNA 调控系统增强 MHC-I 类抗原呈递以逆转肿瘤免疫逃逸

Reversal of tumour immune evasion via enhanced MHC-Class-I antigen presentation by a dual-functional RNA regulated system.

本研究成功构建了一种双功能 RNA 调控系统，该系统可增强肿瘤细胞抗原呈递并重塑 TME 内的免疫格局，从而增强 mRNA 疫苗的抗肿瘤疗效。

mRNA 疫苗与 PERK 抑制剂联合在黑色素瘤治疗中的协同抗肿瘤效应

Synergistic anti-tumor effects of mRNA vaccine and PERK inhibitor combination in melanoma treatment.

纳米抗体介导的 SPECT/CT 成像揭示了程序性死亡配体 1 在响应 CD8(+) T 细胞和 iNKT 细胞激活 mRNA 疫苗时的时空表达

Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8(+) T cell and iNKT cell act