CELL INTELLIGENCE · 肿瘤细胞治疗研究

面向胶质母细胞瘤治疗的下一代 CAR-T 细胞工程改造：受体设计、抗原靶向与治疗持久性创新综述

Engineering next-generation CAR-T cells for glioblastoma treatment: a review of innovations in receptor design, antigen targeting, and therapeutic per

癌胎抗原作为嵌合抗原受体 (CAR)-T 细胞免疫治疗的新兴靶点：机遇与挑战

Oncofetal antigens as emerging targets in chimeric antigen receptor (CAR)-T cell-based immunotherapies: opportunities and challenges.

中枢神经系统肿瘤中的神经炎症

Neuroinflammation in Central Nervous System Tumors.

PDPN 与 GD2 双靶向增强 CAR-T 细胞对胶质母细胞瘤的疗效并促进持久肿瘤控制

Dual targeting of PDPN and GD2 enhances CAR T cell efficacy against glioblastoma and promotes durable tumor control.

胶质瘤免疫监视与免疫治疗应答交汇处的脑屏障

Brain barriers at the crossroads of glioma immune surveillance and immunotherapy response.

FECH：影响 CAR-T 细胞表型与功能的新型代谢靶点

FECH, a novel metabolic target influencing CAR T-cell phenotype and function.

重编程胶质母细胞瘤中的免疫抑制微环境：小胶质细胞-MDSC-Treg 轴及转化治疗策略

Reprogramming the immunosuppressive microenvironment in glioblastoma: the microglia-MDSC-Treg axis and translational therapeutic strategies.

围手术期髓系细胞重塑塑造胶质母细胞瘤中 CAR-T 细胞的疗效

Perioperative myeloid cell remodeling shapes CAR-T cell efficacy in glioblastoma.

心理困扰作为癌症免疫治疗反应的假定宿主状态决定因素

Psychological distress as a putative host-state determinant of cancer immunotherapy response.

免疫基因组图谱揭示儿童脑肿瘤的基因治疗靶点

Immunogenomic profiling reveals targets for gene therapy in pediatric brain tumors.

这种整合分析方法识别出 pDMG 中可靶向的通路、表面抗原和新抗原，支持 CAR-T 和 TCR-T 疗法的开发。这些发现还提示其可能适用于其他携带相同突变的癌症。