CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
肿瘤细胞治疗研究
FRONTIER PAPERS
近 5 年肿瘤细胞治疗领域的研究论文。默认按评分排序(权威性 + 新鲜度)。
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
LRIG2 suppresses NK cell-induced GSDME-mediated pyroptosis via the LAMP1-STAT3 pathway in glioma.
LRIG2 通过 LAMP1-STAT3 通路抑制 NK 诱导的 GSDME 介导的细胞焦亡,从而实现胶质瘤免疫逃逸。靶向该轴是增强基于 NK 细胞的胶质瘤免疫治疗的一种有前景的策略,使 LRIG2 成为潜在的生物标志物和治疗靶点。
AI-driven radiomics and radiogenomics: supporting the assessment and differentiation of pseudoprogression in cellular immunotherapy for glioblastoma.
Correcting Mitochondrial Complex I Defect in Tumor-Associated Natural Killer Cells Potentiates Immunotherapy for Glioblastoma.
Decoding the spatiotemporal dynamics of T cell immune landscapes in glioblastoma: remodeling precision combination therapies.
CAR-T Cell Therapy for Glioblastoma: Obstacles and Advances.
Correction: Dual-modality imaging enables longitudinal biodistribution profiling of intracerebroventricular CAR-T therapy in orthotopic glioma.
Biomimetic PD-1-MSCs membrane-engineered nanoparticles for enhanced blood-brain barrier penetration and anti- glioma therapy.
PD-1 修饰的 MSC 膜仿生纳米平台整合了靶向化疗和免疫检查点抑制。它高效穿越 BBB,特异性蓄积于胶质瘤组织,发挥强效抗肿瘤作用,并改善肿瘤免疫微环境,具有良好的生物安全性。本研究为胶质瘤精准治疗提供了一种新颖且有前景的仿生化疗免疫治疗策略。
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