CELL INTELLIGENCE · 肿瘤细胞治疗研究

面向胶质母细胞瘤治疗的下一代 CAR-T 细胞工程改造：受体设计、抗原靶向与治疗持久性创新综述

Engineering next-generation CAR-T cells for glioblastoma treatment: a review of innovations in receptor design, antigen targeting, and therapeutic per

癌胎抗原作为嵌合抗原受体 (CAR)-T 细胞免疫治疗的新兴靶点：机遇与挑战

Oncofetal antigens as emerging targets in chimeric antigen receptor (CAR)-T cell-based immunotherapies: opportunities and challenges.

PDPN 与 GD2 双靶向增强 CAR-T 细胞对胶质母细胞瘤的疗效并促进持久肿瘤控制

Dual targeting of PDPN and GD2 enhances CAR T cell efficacy against glioblastoma and promotes durable tumor control.

FECH：影响 CAR-T 细胞表型与功能的新型代谢靶点

FECH, a novel metabolic target influencing CAR T-cell phenotype and function.

围手术期髓系细胞重塑塑造胶质母细胞瘤中 CAR-T 细胞的疗效

Perioperative myeloid cell remodeling shapes CAR-T cell efficacy in glioblastoma.

免疫基因组图谱揭示儿童脑肿瘤的基因治疗靶点

Immunogenomic profiling reveals targets for gene therapy in pediatric brain tumors.

这种整合分析方法识别出 pDMG 中可靶向的通路、表面抗原和新抗原，支持 CAR-T 和 TCR-T 疗法的开发。这些发现还提示其可能适用于其他携带相同突变的癌症。

近期复发胶质母细胞瘤局部区域 CAR-T 细胞试验：对神经肿瘤学实践的意义

Recent Locoregional CAR T-Cell Trials for the Treatment of Recurrent Glioblastoma: Implications for Neuro-Oncology Practice.

氯毒素定向进化增强 MMP-2 识别并提升体外胶质母细胞瘤模型中的 CAR-T 细胞活性

Directed evolution of chlorotoxin enhances MMP-2 recognition and improves CAR-T-cell activity in glioblastoma models in vitro.

本研究表明，CTX 的定向进化可产生高亲和力、选择性的 MMP-2 配体，适用于下一代 CAR-T 细胞疗法。基于 CTXA8 的 CAR 具有增强的抗肿瘤疗效，支持其在克服实体瘤免疫治疗挑战方面的潜力。

超越突变：整合放射基因组学、表观遗传学与免疫特征以克服中枢神经系统肿瘤治疗耐药——叙述性综述

Beyond the mutation: integrating radiogenomics, epigenetics, and immune signatures to overcome therapeutic resistance in CNS tumors: a narrative revie

当前的临床前模型是否足以评估 CAR-T 细胞疗法在儿童高级别胶质瘤中的作用？

Are the current preclinical models adequate to evaluate CAR-T cell therapy in pediatric high-grade gliomas?