CELL INTELLIGENCE · 肿瘤细胞治疗研究

自协同 RNA 疫苗减轻树突状细胞介导的获得性免疫抵抗以增强细胞疗法对实体瘤的疗效

Self-Cooperative RNA Vaccine Mitigates Dendritic Cell-Mediated Acquired Immune Resistance to Potentiate Cell Therapy for Solid Tumors.

个性化免疫治疗在 HCC 中的应用：基于 mRNA 疫苗的合成、递送及临床进展

Personalized immunotherapy in HCC: synthesis, delivery, and clinical progress of mRNA-based vaccines.

绘制基于纳米技术的肝细胞癌免疫治疗研究全景

Mapping the research landscape of nanotechnology based immunotherapy for hepatocellular carcinoma.

基于纳米技术的免疫治疗领域已从基础纳米颗粒开发（2005–2009）发展到免疫微环境调控（2010–2018），如今迈入基于 mRNA 的精准免疫治疗（2019–2024）。未来的努力可能优先考虑整合代谢调控和 AI 优化递送的综合纳米免疫治疗。

通过双功能 RNA 调控系统增强 MHC-I 类抗原呈递以逆转肿瘤免疫逃逸

Reversal of tumour immune evasion via enhanced MHC-Class-I antigen presentation by a dual-functional RNA regulated system.

本研究成功构建了一种双功能 RNA 调控系统，该系统可增强肿瘤细胞抗原呈递并重塑 TME 内的免疫格局，从而增强 mRNA 疫苗的抗肿瘤疗效。

经 mRNA-LNP 平台靶向递送 IFN-α-抗 GPC3 融合蛋白在肝细胞癌中激发强效抗肿瘤免疫

Targeted delivery of IFN-α-anti-GPC3 fusion protein via mRNA-LNP platform elicits potent anti-tumor immunity in hepatocellular carcinoma.

纳米材料介导的 CAR-T 增强用于肝细胞癌：革新免疫治疗策略

Nanomaterials Mediated Enhancement of CAR-T for HCC: Revolutionizing Immunotherapy Strategies.

靶向 GPC3 治疗肝细胞癌的进展与挑战

Progress and challenges in glypican-3 targeting for hepatocellular carcinoma therapy.

GPC3 是 HCC 免疫治疗的理想肿瘤抗原。

评估过继转移工程化 TCR-T 细胞体内多功能性的快速方法

A rapid method to assess the in vivo multi-functionality of adoptively transferred engineered TCR T cells.