一项针对异基因造血细胞移植后患有活动性疾病的急性髓系白血病患者的 WT1 特异性 TCR 基因治疗的 I/II 期试验:向 NK 样表型偏移损害 T 细胞功能和持续性
A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell tra
FRONTIER PAPERS
A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell tra
The AML immune paradox: decoding escape pathways and pioneering checkpoint, vaccine, and combination strategies.
Dendritic cell vaccination strategy for the treatment of acute myeloid leukemia: a systematic review.
我们进行了一项系统综述,支持将 DC 疫苗疗法作为 AML 的有效治疗方法。该疗法在实现缓解、增强免疫系统功能和延长总生存期方面显示出潜力。然而,需要更多研究来改进 DC 疫苗的制备和递送方法,并确认其长期安全性和有效性。
Regeneration of antigen-specific T cells by using induced pluripotent stem cell (iPSC) technology.
Acute Myeloid Leukemia Skews Therapeutic WT1-specific CD8 TCR-T Cells Towards an NK-like Phenotype that Compromises Function and Persistence.
NKT-Licensed In Vivo Dendritic Cell-Based Immunotherapy as Cellular Immunodrugs for Cancer Treatment.
Reinvigoration of innate and adaptive immunity via therapeutic cellular vaccine for patients with AML.
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