肿瘤细胞治疗研究
FRONTIER PAPERS
Dimethyl fumarate reprograms cervical cancer cells to enhance antitumor immunity by activating mtDNA-cGAS-STING pathway.
该研究阐明，DMF 重编程 CC 细胞以激活 mtDNA-cGAS-STING 通路，进而形成富含趋化因子的微环境，招募 CD8⁺ T 细胞。
Potent Cytotoxic Tumor-Infiltrating Lymphocytes Can Be Generated from Immune-Excluded Chondrosarcomas Using Regulatable Membrane-Bound IL15.
这些结果提示，有可能为免疫排斥型肿瘤患者开发出有效的无 IL2 的 TIL 疗法。
T cell receptor repertoire characteristics and therapeutic potential of tumor infiltrating lymphocytes (TILs) derived from metastatic lymph node in ce
Discover personalized drug opportunity and optimized tumor-infiltrating lymphocyte therapy for rare cancer: an organoid-based whole-journey clinical m
本研究证实，罕见癌症患者的生存取决于整合的、个体化的伴随诊断与治疗优化。
Multiomics profiling reveals the benefits of gamma-delta (γδ) T lymphocytes for improving the tumor microenvironment, immunotherapy efficacy and progn
γδ T细胞在宫颈癌的抗肿瘤免疫中发挥有益作用。宫颈癌组织中γδ T细胞的丰度与免疫治疗更高的应答率相关。
Adoptive Cell Therapy for Nonhematologic Solid Tumors.
免疫疗法在部分肿瘤中展现的长期益处未能推广到大多数非血液系统实体瘤。
Cellular Immunotherapy for Cervical Cancer: Next Therapeutics Frontiers.
我们得出结论，该领域的未来在于合理的联合策略（例如，与免疫检查点阻断联合）和下一代工程改造（例如，装甲CAR、逻辑门、异体平台），以克服生产复杂性、毒性和高成本。
Phase I study of adjuvant immunotherapy with autologous tumor-infiltrating lymphocytes in locally advanced cervical cancer.
IL-2 注射。结果27 例患者中有 20 例的 TIL 成功扩增，可行性为 74.1%。
Eradicating tumor in a recurrent cervical cancer patient with autologous tumor-infiltrating lymphocytes and a modified lymphodepleting regimen.
她在一次性 TILs 输注后 10 周达到完全缓解。
Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer.
宫颈癌是女性常见的恶性肿瘤，人乳头瘤病毒（HPV）感染是宫颈癌的主要原因。
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