CELL INTELLIGENCE · 肿瘤细胞治疗研究

苯丙氨酸羟化酶作为胰腺癌预后标志物：对肿瘤代谢和免疫微环境的启示

Phenylalanine Hydroxylase as a Prognostic Marker in Pancreatic Cancer: Insights into Tumor Metabolism and Immune Microenvironment.

本研究首次揭示 PAH 作为代谢性免疫调节因子及术后 PC 患者的独立预后因素。PAH 可能通过改变肿瘤微环境影响前列腺癌的结局。

Krüppel 样因子 4，肿瘤微环境中细胞串扰的枢纽门控

Krüppel-Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment.

KLF4 作为枢纽门控，协调 TME 内的细胞串扰。理解其情境依赖性功能可能有助于开发针对 KLF4 的精准肿瘤学疗法。

超声联合微泡介导的肿瘤微环境免疫治疗

Ultrasound combined with microbubble mediated immunotherapy for tumor microenvironment.

CAR-T 细胞对表达 CEACAM5 且耐抗体药物偶联物的非小细胞肺癌细胞有效

Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates.

重组抗 EGFR×抗 CD3 双特异性抗体武装的活化 T 细胞对实体瘤具有广泛反应性和增强效力

Broad reactivity and enhanced potency of recombinant anti-EGFR × anti-CD3 bispecific antibody-armed activated T cells against solid tumours.