CELL INTELLIGENCE · 肿瘤细胞治疗研究

双功能阳离子水凝胶，用于同时预防术后肿瘤复发和伤口感染

Dual-functional cationic hydrogel engineered for simultaneous prevention of postoperative tumor recurrence and wound infection.

基于包被溶瘤病毒的“双重打击”策略在胃肠道肿瘤中触发 CD19 CAR-T 治疗

Coated oncolytic viruses based "double strike" strategy triggering CD19 CAR-T therapy in gastrointestinal tumors.

CAR-T 细胞的制备与静电表面优化提高肝脏恶性肿瘤疗效

Manufacturing and electrostatic surface optimization of CAR-T cells improve therapeutic efficacy in liver malignancies.

CAR-T 结构体的制造条件系统性优化与基于结构的电荷工程协同增强了对肝脏恶性肿瘤的治疗效果，为改善实体瘤 CAR-T 疗法提供了可转化的框架。

靶向 EpCAM 的 CAR-T 细胞疗法 IMC001 的临床前开发及其在晚期胃癌患者中的 1 期试验

Preclinical development and a phase 1 trial of IMC001, an EpCAM-targeted CAR-T cell therapy, in patients with advanced gastric cancer.

可铺展自凝胶止血粉增敏 CAR-NK 细胞治疗以预防肝细胞癌切除后复发

A spreadable self-gelling hemostatic powder sensitizes CAR-NK cell therapy to prevent hepatocellular carcinoma recurrence postresection.

释放 T 细胞监视以清除对新辅助化疗耐药的静息持留肿瘤细胞

Unleashing T cell surveillance for the eradication of quiescent persister tumor cells resistant to neoadjuvant chemotherapy.

靶向 EpCAM 的 CAR-T 细胞免疫治疗在上皮性肿瘤中的安全性与疗效

EpCAM-targeting CAR-T cell immunotherapy is safe and efficacious for epithelial tumors.

靶向 1-磷酸鞘氨醇受体 3 抑制 T 细胞耗竭并调控促炎巨噬细胞募集以改善 CAR-T 细胞对实体瘤的抗肿瘤疗效

Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor

该研究证明，靶向 S1PR3 可增强 CAR-T 细胞疗法的抗肿瘤活性，其机制至少部分是通过抑制 T 细胞耗竭以及通过招募促炎性巨噬细胞重塑 TME 来实现的。

CAR-T 细胞与表达趋化因子和共刺激配体的 aAPCs 共输注增强小鼠抗肿瘤疗效

Co-infusion of CAR T cells with aAPCs expressing chemokines and costimulatory ligands enhances the anti-tumor efficacy in mice.

雷帕霉素预处理恢复 CAR-T 细胞清除骨髓急性髓系白血病细胞的能力

Rapamycin Pretreatment Rescues the Bone Marrow AML Cell Elimination Capacity of CAR-T Cells.

我们的研究揭示了当前 AML 临床试验中报道的 CAR-T 疗效有限的潜在原因，并阐明了一种易于实施的预处理策略，该策略可增强 CAR-T 细胞的抗 AML 疗效。