CELL INTELLIGENCE · 肿瘤细胞治疗研究

NK 细胞来源的细胞外囊泡制剂在体外和体内对人胶质母细胞瘤表现出强效抗肿瘤活性

Natural Killer Cell-Derived Extracellular Vesicle Preparations Demonstrate Potent Antitumor Activity Against Human Glioblastoma In Vitro and In Vivo.

RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍

RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.

IL-15 在固有免疫与适应性免疫界面的反式呈递：机制及其在肿瘤免疫治疗中的转化

IL-15 trans-presentation at the innate-adaptive interface: mechanisms and translation in cancer immunotherapy.

靶向巨噬细胞的癌症治疗策略

Macrophage-directed therapeutic strategies in cancer.

CD200-CD200R 作为实体瘤中的髓系免疫检查点：机制、情境依赖性功能及治疗机会

CD200-CD200R as a myeloid immune checkpoint in solid tumors: mechanisms, context-dependent functions, and therapeutic opportunities.

抗 HLA-E-VL9 抗体增强 NK 细胞和 CD8(+) T 细胞对肿瘤细胞及 HIV 感染 CD4(+) T 细胞的细胞毒性

Antibodies against HLA-E-VL9 enhance NK cell and CD8(+) T cell cytotoxicity against tumor cells and HIV-infected CD4(+) T cells.

工程化益生菌用于肿瘤靶向联合化学免疫治疗

Engineered probiotics for tumor-targeted combination chemoimmunotherapy.

帕博利珠单抗联合二甲双胍治疗转移性头颈部癌的 II 期可行性研究

A Phase II Feasibility Study Combining Pembrolizumab and Metformin in Patients with Metastatic Head and Neck Cancer.

二甲双胍联合帕博利珠单抗耐受性良好，仅出现轻度胃肠道不良事件，并展现出有前景的活性，值得在随机试验中进一步研究。

胰腺肿瘤微环境中代谢-免疫交互的机制及临床意义

Mechanism and clinical relevance of metabolic-immune cross-talk in pancreatic tumor microenvironment.

障碍与蓝图：胃肠道肿瘤中 CAR-T 细胞治疗的下一代工程策略

Barriers and Blueprints: Next-Generation Engineering Strategies for CAR-T Cell Therapy in Gastrointestinal Tumors.