CELL INTELLIGENCE · 肿瘤细胞治疗研究

TP53 缺失通过上调 NF-κB-IFN-β-MHC-Ia 信号促进骨肉瘤对 NK 细胞的抵抗

TP53 Loss Elevates NF-κB-IFN-β-MHC-Ia Signaling to Promote NK Cell Resistance in Osteosarcoma.

甘草查尔酮 B 通过 Hedgehog 信号通路抑制 Neuritin 1 驱动的神经周围侵犯和骨肉瘤进展

Licochalcone B inhibits Neuritin 1-driven perineural invasion and osteosarcoma progression via the Hedgehog signaling pathway.

LCB 通过靶向 NRN1 在 OS 中发挥全面的抗肿瘤作用，同时抑制 Hedgehog 信号通路、减轻神经周围侵犯并恢复 NK 细胞介导的抗肿瘤免疫，这可能成为改善患者预后的一种有前景的治疗策略。

靶向 B7-H3-CAR-T 细胞中的 Regnase-1 重编程肿瘤微环境并增强骨肉瘤抗肿瘤疗效

Targeting Regnase-1 in B7-H3-CAR T cells reprograms the tumor microenvironment and enhances antitumor efficacy for osteosarcoma.

骨肉瘤肿瘤免疫微环境重塑与病理性骨折风险关联的研究进展

Advances in the association between tumor immune microenvironment remodeling in osteosarcoma and the risk of pathological fractures.

骨肉瘤的基因免疫治疗：从溶瘤载体到工程化免疫细胞

Gene-based immunotherapy in osteosarcoma: from oncolytic vectors to engineered immune cells.

输注体外扩增的同种异体犬 NK 细胞治疗转移性实体瘤的安全性和可行性

Safety and Feasibility of Infusing Ex Vivo Expanded Allogeneic Canine Natural Killer Cells for the Treatment of Metastatic Solid Tumours.

重编程过继细胞治疗骨肉瘤：工程化、疫苗接种与肿瘤微环境重塑

Reprogramming adoptive cell therapy for osteosarcoma: engineering, vaccination, and tumor microenvironment remodeling.

骨肉瘤中的代谢-免疫串扰：机制与治疗机会

Metabolic-immune crosstalk in osteosarcoma: mechanisms and therapeutic opportunities.

PSIP1 调控骨肉瘤免疫逃逸：单细胞分析的启示及对免疫治疗耐药的意义

PSIP1 Orchestrates Immune Escape in Osteosarcoma: Insights From Single-Cell Analysis and Implications for Immunotherapy Resistance.

我们的研究将 PSIP1 定位为免疫逃逸的新型调控因子，以及 OS 中免疫治疗耐药的有前景的预测性生物标志物，为克服治疗抵抗提供了一个潜在靶点。

犬骨肉瘤的空间转录组图谱揭示与生存相关的免疫微环境特征

Spatial transcriptomic mapping of canine osteosarcoma reveals immune microenvironment features linked to survival.