CELL INTELLIGENCE · 肿瘤细胞治疗研究

间皮素作为癌症免疫治疗的生物标志物和治疗靶点

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer.

表达还是不表达 HLA-G：组织未分化是胃肠道肿瘤中的答案

To express or not to express HLA-G: tissue undifferentiation is the answer in gastrointestinal tumors.

心理困扰作为癌症免疫治疗反应的假定宿主状态决定因素

Psychological distress as a putative host-state determinant of cancer immunotherapy response.

PPARγ激活使 MSS 胃肠道癌细胞对 PD1 阻断敏感

PPARγ activation sensitizes MSS gastrointestinal cancer cells to PD1 blockage.

PPARγ的药理学激活增强了 PD1 阻断的抗肿瘤疗效。因此，代谢调节剂可能被开发为免疫增敏剂，用于针对 MSS 肿瘤的临床检查点治疗。

评估 pegenzileukin（SAR444245/THOR-707）联合 pembrolizumab 或 cetuximab 治疗晚期转移性胃肠道癌：PEGATHOR 2 期研究

Evaluating pegenzileukin (SAR444245/THOR-707) in combination with pembrolizumab or cetuximab in advanced metastatic gastrointestinal cancer: the PEGAT

通过 CD39 下调增强 CAR-T 细胞功能与代谢

Augmenting CAR T cell functionality and metabolism through CD39 downtuning.

免疫评分及其超越：基于免疫微环境生物标志物在实体瘤中的演变与临床整合

Immunoscore and beyond: evolution and clinical integration of immune contexture-based biomarkers across solid tumours.

靶向胃癌中的 claudin：SPOTLIGHT 中的新型 GLOWing 策略

Targeting claudins in gastric cancer: A novel GLOWing strategy in the SPOTLIGHT.

靶向 γ-分泌酶复合物调控高侵袭性恶性肿瘤中的致癌 NOTCH 信号：一项系统综述

Modulation of Oncogenic NOTCH Signaling in Highly Aggressive Malignancies by Targeting the γ-Secretase Complex: A Systematic Review.

工程化巨噬细胞以实现肿瘤微环境中 CD47 癌细胞的有效且安全靶向

Engineering macrophages for effective and safe targeting of CD47 cancer cells in the tumor microenvironment.