CELL INTELLIGENCE · 肿瘤细胞治疗研究

双特异性 CAR-T 和 CAR-NK 细胞在双重免疫治疗中的机遇与挑战

Bispecific CAR T and CAR NK cells in dual-threat immunotherapy: opportunities and challenges.

CAR-T 细胞治疗在肿瘤免疫治疗中的应用——生物学、临床成功与新兴挑战：综述

CAR-T cell therapy in cancer immunotherapy - Biology, clinical successes, and emerging challenges: A review.

CD3ɛ 纳米抗体工程化细胞外囊泡驱动体内生成分泌 TCE 的 CAR-T 用于具有记忆反应和最小免疫原性的实体瘤治疗

CD3ɛ Nanobody-Engineered Extracellular Vesicles Driving In Vivo Generation of TCE-secreting CAR-Ts for Solid Tumor Therapy With Memory Response and Mi

顺式和反式结合嵌合共刺激受体增强 T 细胞适应性和肿瘤控制

Cis- and trans-binding chimeric costimulatory receptors enhance T-cell fitness and tumor control.

面向实体瘤的 CAR-T 细胞工程化：双特异性抗原靶向、肿瘤微环境调控与毒性控制

Engineering CAR-T cells for solid tumors: bispecific antigen targeting, tumor microenvironment modulation, and toxicity control.

使用经抗 tenascin C CAR 和可分泌 EGFRxCD3 双特异性抗体修饰的细胞因子诱导杀伤细胞对实体瘤进行双重靶向

Dual targeting of solid tumors using cytokine-induced killer cells modified with a CAR anti-tenascin C and a secretable EGFRxCD3 bispecific antibody.

仿生纳米免疫疗法增强时空 PANoptosis 并重塑促结缔组织增生性肿瘤微环境

Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment.

T 细胞免疫球蛋白和 ITIM 结构域作为联合抗 PD-(L)1 肿瘤治疗的靶点

T-cell immunoglobulin and ITIM domain as a target in combo anti-PD-(L)1 cancer therapy.

基于肽的双特异性 CAR-T 细胞靶向 EGFR 和肿瘤基质以实现有效癌症治疗

The peptide-based bispecific CAR T cells target EGFR and tumor stroma for effective cancer therapy.

我们的研究结果表明，基于肽的双特异性 CAR-T 细胞因其对肿瘤及肿瘤微环境的出色靶向能力，在实体瘤治疗中展现出巨大潜力。

碳酸酐酶 IX：肿瘤创新治疗的非典型靶点

Carbonic anhydrase IX: An atypical target for innovative therapies in cancer.