胶质母细胞瘤的代谢与翻译后脆弱性:二硫死亡、糖基化及对 CAR-T 治疗的启示
Metabolic and Post-Translational Vulnerabilities of Glioblastoma: Disulfidptosis, Glycosylation, and Implications for CAR-T Therapy.
胶质母细胞瘤(GB)仍是治疗抵抗性最强的实体瘤之一,其特征是显著的代谢可塑性、瘤内异质性和高度免疫抑制的微环境。
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Metabolic and Post-Translational Vulnerabilities of Glioblastoma: Disulfidptosis, Glycosylation, and Implications for CAR-T Therapy.
胶质母细胞瘤(GB)仍是治疗抵抗性最强的实体瘤之一,其特征是显著的代谢可塑性、瘤内异质性和高度免疫抑制的微环境。
CAR T cell therapy for glioblastoma: A review of the first decade of clinical trials.
胶质母细胞瘤(GBM)是一种侵袭性原发性脑肿瘤,预后不良,有效治疗方案很少。
Natural killer cell dysfunction in glioma: from immune evasion to immunotherapy.
自然杀伤(NK)细胞是固有免疫的关键组成部分,无需预先致敏即具有清除肿瘤细胞的能力。
CAR T Cell Therapy in Primary Brain Tumors: Current Investigations and the Future.
CAR-T 细胞(CAR T细胞)是经过工程化改造的细胞,表达针对特定肿瘤抗原(TA)的嵌合抗原受体(CAR),从而能够识别并清除癌细胞。
Mathematical modeling of combinatorial antigen targeting with multiple CAR T-cell products for glioblastoma treatment.
例如,同时给药时肿瘤缩小百分比为 7.1%,而序贯给药时为 6.7%。
Clinical progress in the development of CAR T cells to treat malignant glioma.
在研 CAR-T 细胞疗法的快速演进预示着胶质瘤治疗未来的巨大潜力。
Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer.
我们的结果表明,7 19 CAR-T可能成为胶质母细胞瘤和胰腺癌的一种治疗选择。
Study of combination CAR T-cell treatment for glioblastoma using mathematical modeling.
胶质母细胞瘤是一种高度侵袭性、难以治疗且对常规疗法耐药的脑癌。
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