单细胞追踪揭示黑色素瘤 TIL 治疗过程中肿瘤反应性 T 细胞的可塑性
Single-cell tracking reveals tumor-reactive T cell plasticity during melanoma TIL therapy.
TIL（肿瘤浸润淋巴细胞）过继细胞治疗可在转移性黑色素瘤中诱导持久缓解，然而在体外扩增过程中及回输后，调控肿瘤反应性T细胞命运的克隆和转录动态仍知之甚少。
98.5分
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CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
钙库操控性钙信号调节剂改善基于树突状细胞的黑色素瘤疫苗
英文原题：Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma.
研究概要
Cruz Cobo等人鉴定出可将树突状细胞重编程为免疫刺激性分泌表型的小分子，揭示内质网钙信号通路是一个可成药的靶点，可用于增强基于疫苗和T细胞介导的癌症免疫治疗。
中文摘要
Cruz Cobo等人鉴定出可将树突状细胞重编程为免疫刺激性分泌表型的小分子，揭示内质网钙信号是一个可成药的靶点，可增强基于疫苗和T细胞介导的癌症免疫治疗。该研究将钙诱导分泌的广泛变化与免疫激活和治疗效力的改善联系起来。
展开英文摘要原文
Cruz Cobo et al. identify small molecules that reprogram dendritic cells toward an immuno-stimulating secretory phenotype, revealing endoplasmic reticulum calcium signaling as a druggable axis to boost vaccine-based and T cell-mediated cancer immunotherapies. The study links broad changes in calcium-induced secretion to improved immune activation and therapeutic potency.
论文信息
- 作者
- Cruz Cobo M、Garnier L、Mandavit M、Azam M、Quadri ID、Angelillo J、Brighouse D、Bausart M
- 单位
- Geneva Center for Inflammation Research, Faculty of Medicine, Pathology and Immunology Department, University of Geneva, Geneva, Switzerland.Switzerland
- 期刊
- Oncoimmunology2026 Dec 31
- 原文标识
- PubMed 42666008 · DOI 10.1080/2162402X.2026.2723541