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γδ T 细胞研究进展:皮肤生物学及其对皮肤肿瘤的治疗潜力

英文原题:Advances in γδ T Cells: Cutaneous Biology and Therapeutic Potential for Skin Neoplasms.

PubMed 2026/08/21(内容时间) J Dermatol Q2 · IF 2.3(JCR 2025)

研究概要

γδ T细胞在抗肿瘤免疫反应中代表着一个日益重要的T淋巴细胞亚群,并作为新型免疫疗法的平台。

中文摘要

γδ T 细胞在抗肿瘤免疫应答中代表一个日益重要的 T 淋巴细胞亚群,并作为新型免疫疗法的平台。本综述的目的是在肿瘤免疫学和近期临床研究的框架内,综合近期对 γδ T 细胞在皮肤恶性肿瘤(尤其是黑色素瘤)中的生物学见解和治疗应用进展。

展开英文摘要原文

γδ T cells represent an increasingly important subset of T lymphocytes in the immune response to cancer and as a platform for novel immunotherapies. The aim of this review is to synthesize recent insights into the biology and advances in therapeutic applications of γδ T cells in cutaneous malignancies, especially melanoma, within a framework of tumor immunology and recent clinical research.

论文信息

作者
Du S、Jallorina A、Yoshino T、Bao L、Bao H、Chang V、Wong HK、Chan DV
第一作者单位
Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.United States
通讯作者单位
Icahn School of Medicine at Mount Sinai, New York, New York, USA.United States
文献类型
综述
期刊
The Journal of dermatology2026 Aug 21
原文标识
PubMed 42630030 · DOI 10.1111/1346-8138.70461