肿瘤细胞治疗研究
英文原题：Enhancing CAR-NK persistence to unlock its full therapeutic potentials.
Enhancing CAR-NK persistence to unlock its full therapeutic potentials.
嵌合抗原受体NK 细胞（CAR-NK）是一种有前景的下一代免疫疗法。
嵌合抗原受体-NK 细胞（CAR-NK）是一种有前景的下一代免疫疗法。CAR-NK细胞疗法的持久性被认为是限制其充分发挥治疗潜力的关键障碍。本综述重点阐述了CAR-NK持久性不佳的原因，并总结了在血液系统恶性肿瘤和实体瘤中为提高CAR-NK持久性而开发的策略。这些策略包括细胞因子及细胞因子信号介导的策略；NK细胞来源和CAR设计的优化；内在和外在检查点阻断及代谢重编程；以及淋巴细胞清除、同种异体逃逸和自相残杀逃逸策略。多种旨在提高体内持久性的策略应有助于增强CAR-NK的治疗疗效。
Chimeric Antigen Receptor-Natural Killer Cell (CAR-NK) is a promising next-generation immunotherapy. Persistence of CAR-NK cell therapy is considered a key hurdle limiting its full therapeutic potential. This review highlighted the causes of poor CAR-NK persistence and summarized strategies developed to improve CAR-NK persistence in both hematologic malignancies and solid tumors. These strategies included cytokine and cytokine signaling mediated strategies; optimization of NK cell source and CAR design; intrinsic and extrinsic checkpoint disruption and metabolic reprogramming; and lymphodepletion, alloevasion and fratricide evasion strategies. Multiple strategies that aim at improving in vivo persistence should prove useful in enhancing therapeutic efficacy of CAR-NK.
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