肿瘤细胞治疗研究
英文原题：Successful Postpartum CAR T-cell Salvage Therapy for Primary Mediastinal Large B-cell Lymphoma with Residual Disease after R-CHOP During Pregnancy.
Successful Postpartum CAR T-cell Salvage Therapy for Primary Mediastinal Large B-cell Lymphoma with Residual Disease after R-CHOP During Pregnancy.
我们报告一例 29 岁女性，于妊娠 19 周时诊断为 PMBCL，尽管已确诊仍希望继续妊娠。
妊娠期间发生原发性纵隔大B细胞淋巴瘤（PMBCL）较为罕见，胎儿安全问题使治疗面临挑战。我们报告一例29岁女性患者，在妊娠19周时确诊PMBCL；尽管确诊，她仍希望继续妊娠。在多学科管理下，患者接受利妥昔单抗、环磷酰胺、多柔比星、长春新碱和泼尼松龙（R-CHOP）化疗，并足月分娩一名健康婴儿。肿瘤虽部分应答，但完成8个疗程后仍有残留病灶。随后患者接受CAR-T 细胞治疗并达到完全缓解。本病例凸显了妊娠期间管理PMBCL时个体化治疗决策和多学科协作的重要性。
Primary mediastinal large B-cell lymphoma (PMBCL) during pregnancy is rare and presents therapeutic challenges due to fetal safety concerns. We report the case of a 29-year-old woman diagnosed with PMBCL at 19 weeks of gestation who wished to continue her pregnancy despite her diagnosis. She received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) chemotherapy with multidisciplinary management and delivered a healthy infant at term. Although the tumor partially responded, residual disease persisted after eight cycles of treatment. She subsequently underwent chimeric antigen receptor T-cell therapy and achieved a complete response. This case highlights the importance of individualized treatment decisions and multidisciplinary collaboration in managing PMBCL during pregnancy.
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