肿瘤细胞治疗研究
英文原题：Pre-Transplant Natural Killer Cell Activity Predicts Survival and Tumor Recurrence After Living Donor Liver Transplantation.
Pre-Transplant Natural Killer Cell Activity Predicts Survival and Tumor Recurrence After Living Donor Liver Transplantation.
结果：被归类为高 NK 活性（10 pg/mL）的患者相比低活性患者，总生存期显著更好（log-rank p = 0.032）。
背景/目的：自然杀伤（NK）细胞是固有免疫防御的重要介质，在肝移植（LT）后的肿瘤监视中发挥关键作用。尽管如此，移植前NK细胞活性在活体供肝移植（LDLT）中的预后相关性尚未完全明确。方法：本回顾性分析纳入134例接受LDLT的成年患者。移植前通过干扰素释放试验评估NK细胞活性，并分为低活性（<10 pg/mL）或高活性（≥10 pg/mL）。对所有参与者评估总生存期（OS），而对HCC患者分析无复发生存期（RFS）。结果：与低活性患者相比，高NK活性（≥10 pg/mL）患者的总生存期显著更好（log-rank p = 0.032）。在多变量分析中，高NK活性显示出改善总生存期的强烈趋势（HR，0.52；95% CI，0.26-1.04；p = 0.063）。在HCC受者中，高NK活性与无复发生存期显著改善相关（log-rank p = 0.004）。多变量Cox回归进一步确定NK活性是肿瘤复发的独立因素（HR，0.27；95% CI，0.08-0.87；p = 0.028）。结论：移植前NK细胞活性可独立预测LDLT后的生存和复发。
Background/Objectives : Natural killer (NK) cells are essential mediators of innate immune defense and play a key role in tumor surveillance following liver transplantation (LT). Despite this, the prognostic relevance of pre-transplant NK cell activity in living donor LT (LDLT) has not been fully established. Methods : This retrospective analysis included 134 adult patients who underwent LDLT. NK cell activity was evaluated prior to transplantation using interferon- release assays and classified as low (<10 pg/mL) or high ( 10 pg/mL). Overall survival (OS) was assessed for all participants, whereas recurrence-free survival (RFS) was analyzed patients with HCC. Results : Patients classified as having high NK activity ( 10 pg/mL) experienced significantly better overall survival compared to those with low activity (log-rank p = 0.032). In the multivariate analysis, high NK activity showed a strong trend toward improved overall survival (HR, 0.52; 95% CI, 0.26-1.04; p = 0.063). Among recipients with HCC, high NK activity was associated with a markedly improved recurrence-free survival (log-rank p = 0.004). Multivariate Cox regression further established NK activity as an independent factor for tumor recurrence (HR, 0.27; 95% CI, 0.08-0.87; p = 0.028). Conclusions : Pre-transplant NK cell activity independently predicts both survival and recurrence following LDLT.
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