肿瘤细胞治疗研究
英文原题：Bringing natural killer cells to the clinic: Opportunities beyond cancer.
自然杀伤（NK）细胞是具有细胞毒性和产生细胞因子能力的先天淋巴细胞，在抗病毒和抗肿瘤免疫中已确立作用。
自然杀伤（NK）细胞是具有细胞毒性并产生细胞因子的固有淋巴细胞，在抗病毒和抗肿瘤免疫中已确立作用。近年来，NK细胞的生物学特性已被用于创新的癌症免疫疗法，带来了临床进展，包括同种异体NK细胞输注、嵌合抗原受体NK细胞和NK细胞衔接器技术。这些研究为探索基于NK细胞的免疫疗法进展如何能在肿瘤学之外被利用，以在病毒感染、神经退行性疾病、自身免疫和移植医学中选择性靶向致病细胞并恢复组织稳态，铺平了道路。
Natural killer (NK) cells are cytotoxic and cytokine-producing innate lymphocytes with established roles in antiviral and antitumor immunity. In recent years, the biology of NK cells has been exploited in innovative cancer immunotherapies, leading to clinical advances including allogeneic NK cell infusions, chimeric antigen receptor NK cells, and NK cell engager technologies. These studies pave the way to explore how advances in NK cell-based immunotherapies could be leveraged outside of oncology to selectively target pathogenic cells and restore tissue homeostasis in viral infections, neurodegenerative disorders, autoimmunity, and transplantation medicine.
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