肿瘤细胞治疗研究
英文原题：Dual regulatory role of natural killer T cells during development of hepatocellular carcinoma.
Dual regulatory role of natural killer T cells during development of hepatocellular carcinoma.
这些发现表明，NKT细胞在肿瘤早期发展中起作用，但可能在后期阶段有助于控制肿瘤进展。
自然杀伤T（NKT）细胞在肝细胞癌（HCC）进展中发挥复杂作用。利用二乙基亚硝胺（DEN）诱导的HCC小鼠模型，我们观察到恶性肝组织内NKT细胞因凋亡而显著减少，剩余细胞表现出细胞因子产生和细胞毒性潜力受损。缺乏NKT细胞的CD1d缺陷小鼠显示出肿瘤起始延迟且肿瘤数量减少，但形成的肿瘤更大，并表现出增强的增殖和免疫抑制。值得注意的是，肿瘤建立后过继转移健康NKT细胞可减轻肿瘤负荷，提示其在疾病后期具有保护作用。这些发现表明，NKT细胞促进早期肿瘤发展，但可能有助于在后期控制肿瘤进展。其在HCC中的功能受损凸显了恢复其抗肿瘤活性策略的必要性。理解NKT细胞在肝癌发生中的双重作用可能为改善HCC治疗和患者预后的新型免疫治疗方法铺平道路。
Natural killer T (NKT) cells play a complex role in hepatocellular carcinoma (HCC) progression. Using a diethylnitrosamine (DEN)-induced HCC mouse model, we observed a significant reduction in NKT cells within malignant liver tissue due to apoptosis, with the remaining cells exhibiting impaired cytokine production and cytotoxic potential. CD1d-deficient mice, which lack NKT cells, showed delayed tumor initiation and fewer tumors, yet the tumors that did form were larger and exhibited enhanced proliferation and immunosuppression. Notably, adoptive transfer of healthy NKT cells after tumor establishment reduced tumor burden, suggesting a protective role in later disease stages. These findings indicate that NKT cells contribute to early tumor development but may help control tumor progression in later stages. Their functional impairment in HCC underscores the need for strategies to restore their anti-tumor activity. Understanding the dual role of NKT cells in liver carcinogenesis may pave the way for novel immunotherapeutic approaches to improve HCC treatment and patient outcomes.
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