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γδT 细胞与乳腺癌:邪恶的盟友

英文原题:γδT cells and breast cancer: wicked allies.

PubMed 2025/09/08(内容时间) Trends Cancer Q1 · IF 21.6(JCR 2025)

研究概要

转移性疾病和治疗耐药性是乳腺癌治疗中的重大挑战。

中文摘要

转移性疾病和治疗耐药性是乳腺癌治疗中的重大挑战。Rozalén等人和Petroni等人的近期研究揭示了产生IL-17A的γδT细胞在肝转移和治疗耐药性中的关键作用,为这些过程的机制提供了新的见解。

展开英文摘要原文

Metastatic disease and therapy resistance pose significant challenges in the treatment of breast cancer. Recent studies by Rozalén et al. and Petroni et al. uncover a crucial role for IL-17A-producing γδT cells in liver metastasis and therapeutic resistance, offering new insights into the mechanisms underlying these processes.

论文信息

作者
Mallu ACT、Coffelt SB
第一作者单位
School of Cancer Sciences, University of Glasgow, Glasgow, UK; Cancer Research UK Scotland Institute, Glasgow, UK.United Kingdom
通讯作者单位
School of Cancer Sciences, University of Glasgow, Glasgow, UK; Cancer Research UK Scotland Institute, Glasgow, UK. Electronic address: seth.coffelt@glasgow.ac.uk.United Kingdom
期刊
Trends in cancer2025 Oct
原文标识
PubMed 40925842 · DOI 10.1016/j.trecan.2025.08.015