肿瘤细胞治疗研究
英文原题：Cytokine Networks in Triple-Negative Breast Cancer: Mechanisms, Therapeutic Targets, and Emerging Strategies.
Cytokine Networks in Triple-Negative Breast Cancer: Mechanisms, Therapeutic Targets, and Emerging Strategies.
三阴性乳腺癌（TNBC）因其侵袭性强且缺乏靶向治疗，仍是乳腺癌中一个具有挑战性的亚型。
由于侵袭性强且缺乏靶向疗法，三阴性乳腺癌（TNBC）仍是难以治疗的乳腺癌亚型。细胞因子在塑造肿瘤微环境中发挥关键作用，可调节肿瘤进展、免疫逃逸和治疗耐药。本综述讨论参与TNBC生物学过程的复杂细胞因子网络，重点介绍其对增殖、血管生成、上皮-间质转化和免疫调节等关键致癌过程的影响。我们还总结当前及新兴的细胞因子靶向治疗策略，包括单克隆抗体、双特异性抗体、细胞疗法，以及经细胞因子装甲化的CAR-T和CAR-NK细胞疗法，并重点讨论其临床意义与未来方向。
Triple-negative breast cancer (TNBC) remains a challenging subtype of breast cancer due to its aggressive nature and lack of targeted therapies. Cytokines play a pivotal role in shaping the tumor microenvironment, modulating tumor progression, immune evasion, and therapy resistance. In this review, we discuss the complex cytokine networks involved in TNBC biology, highlighting their contribution to key oncogenic processes, including proliferation, angiogenesis, epithelial-mesenchymal transition, and immunomodulation. We also summarize current and emerging cytokine-targeted therapeutic strategies, including monoclonal antibodies, bispecific antibodies, cell-based therapies, and cytokine-armed CAR-T and CAR-NK cell approaches, with a focus on clinical implications and future directions.
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