肿瘤细胞治疗研究
英文原题：Exosomes Derived from Induced and Wharton's Jelly-Derived Mesenchymal Stem Cells Promote Senescence-like Features and Migration in Cancer Cells.
间充质干细胞来源的外泌体（MSC-Exos）在组织修复、免疫调节和肿瘤生物学中发挥关键作用。
间充质干细胞来源的外泌体（MSC-Exos）在组织修复、免疫调节和肿瘤生物学中发挥关键作用。由于MSC扩增的限制和来源的变异性，研究兴趣已转向诱导多能干细胞来源的MSC（iMSC）作为有前景的替代来源。本研究比较了iMSC来源的外泌体（iMSC-Exos）和沃顿胶MSC来源的外泌体（WJMSC-Exos）对MCF7和A549癌细胞的影响。两种外泌体均降低了MCF7的增殖并诱导了衰老样状态，而非凋亡，尽管在A549细胞中抗增殖效应是短暂的。值得注意的是，WJMSC-Exos促进了MCF7和A549的迁移，而iMSC-Exos未表现出此效应。总体而言，WJMSC-Exos对癌细胞增殖和迁移的影响更为显著。这些发现凸显了外泌体对癌症的多样化效应以及衰老样状态的形成作为对外泌体暴露的重要反应。此外，这些发现提示需要对iMSC来源外泌体的治疗作用进行更审慎的评估。
Mesenchymal stem cell-derived exosomes (MSC-Exos) play a key role in tissue repair, immune regulation, and cancer biology. Due to limitations in MSC expansion and source variability, interest has shifted to induced pluripotent stem cell-derived MSCs (iMSCs) as a promising alternative. This study compares effects of exosomes derived from iMSCs (iMSC-Exos) and Wharton's jelly MSCs (WJMSC-Exos) on MCF7 and A549 cancer cells. Both types of exosomes reduced MCF7 proliferation and induced a senescence-like state, rather than apoptosis, although the antiproliferative effect was transient in A549 cells. Notably, WJMSC-Exos promoted migration in both MCF7 and A549, whereas iMSC-Exos did not exhibit this effect. Overall, WJMSC-Exos had a more robust impact on cancer cell proliferation and migration. These findings highlight the diverse effects of exosomes on cancer and the development of a senescence-like state as an important response to Exos exposure. Moreover, these findings invite for more careful evaluation of the therapeutic role of iMSC-derived Exos.
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