靶向 Wilms 瘤 1 抗原的树突状细胞疫苗减少髓源性抑制细胞对急性白血病患者临床结局的影响

英文原题：Impact of Reduction in Myeloid-derived Suppressor Cells by Wilms' Tumor 1-targeted Dendritic Cell Vaccines on Clinical Outcomes in Acute Leukemia Patients.

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Impact of Reduction in Myeloid-derived Suppressor Cells by Wilms' Tumor 1-targeted Dendritic Cell Vaccines on Clinical Outcomes in Acute Leukemia Patients.

PubMed 2025/05/14（内容时间） EJHaem Q4 · IF 1.3（JCR 2025）

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靶点：WT1 技术：树突状细胞疫苗白血病地区：日本

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研究概要

这些发现表明 WT1-DC 疫苗抑制 MDSCs 并改善临床结局。

研究思路结论见上方概要

背景

髓源性抑制细胞（MDSCs）在免疫治疗中发挥关键作用。

方法

我们研究了负载Wilms瘤1（WT1）肽的树突状细胞（DC）疫苗对急性白血病患者中MDSCs的影响。

结果

WT1-DC疫苗降低了MDSCs并增强了WT1特异性免疫。在完全缓解患者中，MDSC减少伴随精氨酸酶1和吲哚胺2,3-双加氧酶水平下降以及血浆中白细胞介素（IL）-12和干扰素-γ水平升高。相反，疾病进展患者显示IL-10和转化生长因子-β1升高。MDSCs减少与WT1特异性免疫激活相关，并与更长的生存期相关。

展开英文摘要原文

BACKGROUND

Myeloid-derived suppressor cells (MDSCs) play a critical role in immunotherapy.

METHODS

We investigated the effects of the Wilms' tumor 1 (WT1) peptide-loaded dendritic cell (DC) vaccination on MDSCs in patients with acute leukemia.

RESULTS

WT1-DC vaccination reduced MDSCs and enhanced WT1-specific immunity. In complete remission patients, MDSC reduction was accompanied by decreased arginase 1 and indoleamine 2,3-dioxygenase levels and increased interleukin (IL)-12 and interferon-γ levels in plasma. Conversely, patients with disease progression showed increased IL-10 and transforming growth factor-β1. Reduced MDSCs were correlated with WT1-specific immune activation and associated with longer survival.

CONCLUSION

These findings indicate that WT1-DC vaccination suppresses MDSCs and improves clinical outcomes. CLINICAL TRIAL REGISTRATION: This study is registered with the University Hospital Medical Information Network (UMIN) in Japan (Registration ID: UMIN000027279).

论文信息

作者: Ogasawara M、Miyashita M、Yamagishi Y、Ota S
单位: Department of Hematology Sapporo Hokuyu Hospital Sapporo Japan.Japan
期刊: EJHaem2025 Jun

原文标识: PubMed 40370631　·　DOI 10.1002/jha2.70048

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