肿瘤细胞治疗研究
英文原题：Mapping the landscape of gastric cancer immunotherapy: Bibliometric insights into advances and hotspots.
Mapping the landscape of gastric cancer immunotherapy: Bibliometric insights into advances and hotspots.
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GC 免疫治疗研究是一个不断扩展、吸引大量科学关注的领域。
免疫治疗已成为胃癌（GC）的一种有前景的治疗方式。全面回顾胃癌免疫治疗的进展、现状和研究趋势，有助于指导未来研究。
描述胃癌免疫治疗的趋势、进展和研究重点。
对 Web of Science 核心合集收录的 2000 年至 2023 年 12 月 20 日发表的 2,906 篇英文胃癌免疫治疗论文开展文献计量分析。使用 CiteSpace（6.1.6R）、VOSviewer（v.1.6.17）和 GraphPad Prism（v8.0.2）进行数据分析和可视化。
胃癌免疫治疗研究的年度发文量持续增长。中国发文量居首，美国的引文影响力最高。复旦大学在引文频次和发文量方面表现突出。共被引分析和关键词频次揭示了研究对胃癌预后、肿瘤微环境（TME）以及免疫治疗与靶向治疗整合的关注。新兴研究领域包括胃食管结合部癌、过继性免疫治疗以及 Treg 细胞在免疫治疗中的作用。
胃癌免疫治疗是持续扩展并受到广泛科学关注的领域。随着免疫治疗在胃癌中的临床应用，主要目标是提高治疗效果和患者结局。与血液系统恶性肿瘤不同，胃癌实体肿瘤的 TME 带来独特的免疫学挑战，可能削弱免疫细胞对癌细胞的细胞毒作用。例如，CAR-T 在血液系统恶性肿瘤中有效，但在胃癌中的表现尚不理想。目前研究聚焦于克服 TME 内的免疫抑制，重点包括靶向治疗联合、过继性免疫治疗、Treg 细胞动态变化以及精准预测免疫治疗预后。此外，免疫治疗在胃食管结合部癌中的作用已成为新的研究重点。
Immunotherapy has surfaced as a promising therapeutic modality for gastric cancer (GC). A comprehensive review of advancements, current status, and research trends in GC immunotherapy is essential to inform future investigative efforts. AIM: To delineate the trends, advancements, and focal points in immunotherapy for GC.
We performed a bibliometric analysis of 2906 articles in English concerning GC immunotherapy published from 2000 to December 20, 2023, indexed in the Web of Science Core Collection. Data analysis and visualization were facilitated by CiteSpace (6.1.6R), VOSviewer v.1.6.17, and GraphPad Prism v8.0.2.
There has been an increase in the annual publication rate of GC immunotherapy research. China leads in publication volume, while the United States demonstrates the highest citation impact. Fudan University is notable for its citation frequency and publication output. Co-citation analysis and keyword frequency revealed and highlighted a focus on GC prognosis, the tumor microenvironment (TME), and integrative immunotherapy with targeted therapy. Emerging research areas include gastroesophageal junction cancer, adoptive immunotherapy, and the role of Treg cell in immunotherapy.
GC immunotherapy research is an expanding field attracting considerable scientific interest. With the clinical adoption of immunotherapy in GC, the primary goals are to enhance treatment efficacy and patient outcomes. Unlike hematological malignancies, GC's solid TME presents distinct immunological challenges that may attenuate the cytotoxic effects of immune cells on cancer cells. For instance, although CAR-T therapy is effective in hematological malignancies, it has underperformed in GC settings. Current research is centered on overcoming immunosuppression within the TME, with a focus on combinations of targeted therapy, adoptive immunotherapy, Treg cell dynamics, and precise prognosis prediction in immunotherapy. Additionally, immunotherapy's role in treating gastroesophageal junction cancer has become a novel research focus.
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