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食管癌的细胞免疫治疗

英文原题:Cell-based immunotherapy in oesophageal cancer.

PubMed 2025/03/17(内容时间) J Drug Target Q1 · IF 4.7(JCR 2025)

研究概要

食管癌(EC)是全球最常见的疾病之一,其预后不佳。

中文摘要

食管癌(EC)是全球最常见的疾病之一,其预后不佳。手术、放疗和化疗是EC的主要治疗选择。尽管这些传统治疗方式偶尔有效,但EC患者仍面临局部复发和转移的显著风险。因此,需要创新且有效的药物。近几十年来,临床实践已有效实施细胞疗法,包括基于干细胞和非干细胞的方案,作为一种创新的肿瘤治疗手段,为食管鳞状细胞癌(ESCC)患者带来了新的希望。本文探讨了EC患者细胞治疗的理论框架和当代进展。我们进一步描述了当前的临床研究,并总结了与生存率和安全性评估相关的关键数据。

展开英文摘要原文

Oesophageal cancer (EC) is among the most common illnesses globally, and its prognosis is unfavourable. Surgery, radiotherapy and chemotherapy are the primary therapy options for EC. Despite the occasional efficacy of these traditional treatment modalities, individuals with EC remain at a significant risk for local recurrence and metastasis. Consequently, innovative and efficacious medicines are required. In recent decades, clinical practice has effectively implemented cell therapy, which includes both stem cell and non-stem cell-based approaches, as an innovative tumour treatment, offering renewed hope to patients with oesophageal squamous cell carcinoma (ESCC). This paper examines the theoretical framework and contemporary advancements in cell treatment for individuals with EC. We further described current clinical studies and summarised essential data related to survival and safety assessments.

论文信息

作者
Lahouty M、Soleymanzadeh A、Kazemi S、Saadati-Maleki H、Masoudi S、Ghasemi A、Kazemi T、Mehranfar S
第一作者单位
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Iran
通讯作者单位
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.Iran
文献类型
综述 · 非美国政府资助研究
期刊
Journal of drug targeting2025 Aug
原文标识
PubMed 40063049 · DOI 10.1080/1061186X.2025.2477077