肿瘤细胞治疗研究
英文原题：Application of adoptive cell therapy in malignant melanoma.
皮肤黑色素瘤是起源于皮肤色素细胞的最具侵袭性的皮肤癌之一。
皮肤黑色素瘤是起源于皮肤色素细胞的最具侵袭性的皮肤癌之一。晚期黑色素瘤患者预后较差，由于转移和耐药性，通常无法从手术切除和化疗/靶向治疗中获益。因此，采用具有特异性肿瘤识别受体的免疫细胞的过继细胞疗法（ACT），已成为一种有前景的治疗方法，展现出对肿瘤的毒性作用。本综述讨论了四种常用方法——包括TIL（肿瘤浸润淋巴细胞）、嵌合抗原受体（CAR）T细胞、工程化T细胞受体T细胞和嵌合抗原受体NK细胞——在恶性黑色素瘤中的应用、疗效、局限性及未来前景。
Cutaneous melanoma is one of the most aggressive skin cancers originating from skin pigment cells. Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. Thus, adoptive cell therapy (ACT), employing immune cells with specific tumor-recognizing receptors, has emerged as a promising therapeutic approach to display on-tumor toxicity. This review discusses the application, efficacy, limitations, as well as future prospects of four commonly utilized approaches -including tumor-infiltrating lymphocytes, chimeric antigen receptor (CAR) T cell, engineered T-cell receptor T cells, and chimeric antigen receptor NK cells- in the context of malignant melanoma.
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