更正：B7-H3 CAR-T 细胞清除肝内胆管癌并诱导持久应答
Correction: B7-H3 CAR T cells eradicate intrahepatic cholangiocarcinoma and induce durable response.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
细胞因子诱导的杀伤细胞治疗联合高剂量维生素 C 对胆管癌的长期肿瘤抑制：一例病例报告
英文原题：Long-term tumor suppression in cholangiocarcinoma using cytokine-induced killer cell therapy and high-dose vitamin C: a case report.
查看英文原题
Long-term tumor suppression in cholangiocarcinoma using cytokine-induced killer cell therapy and high-dose vitamin C: a case report.
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中文摘要
本病例研究探讨了自体细胞因子诱导的杀伤（CIK）细胞免疫治疗在一名49岁男性不可手术的IIIb期胆管癌患者中的有效性，该患者免疫细胞中钠依赖性维生素C转运体-2（SVCT2）水平较高。尽管化疗后肿瘤最初未见缩小，但患者在接受放疗和质子治疗后，肿瘤标志物显著下降，肿瘤稳定。随后，CIK细胞治疗联合高剂量维生素C，在6年内共进行52次。患者肿瘤体积缩小，诊断后7年10个月未检测到癌症活动，表明长期结果成功且无复发。本研究提示，CIK细胞治疗，尤其是在SVCT2水平升高的患者中，可能为胆管癌及潜在其他癌症提供一种有前景的辅助治疗。需要进一步研究以验证SVCT2作为CIK细胞治疗有效性的生物标志物。
展开英文摘要原文
This case study explores the effectiveness of autologous cytokine-induced killer (CIK) cell-based immunotherapy in a 49-year-old male patient with inoperable stage IIIb cholangiocarcinoma, characterized by high levels of the sodium-dependent vitamin C transporter-2 (SVCT2) in immune cells.
Despite an initial lack of tumor reduction following chemotherapy, the patient showed a significant decrease in tumor markers and stabilization of the tumor after undergoing radiation and proton therapy. Subsequently, CIK cell therapy, combined with high-dose vitamin C, was administered 52 times over 6 years. The patient's tumor size reduced, and no cancer activity was detected for 7 years and 10 months post-diagnosis, indicating a successful long-term outcome without recurrence.
This study suggests that CIK cell therapy, particularly in patients with elevated SVCT2 levels, may offer a promising adjuvant treatment for cholangiocarcinoma and potentially other cancers.
Further research is needed to validate SVCT2 as a biomarker for the effectiveness of CIK cell therapy.
论文信息
- 作者
- Kim K、Wang H、Lee J、Yeom C
- 第一作者单位
- Department of Surgery, Bangre Hospital, Incheon, Korea.South Korea
- 通讯作者单位
- Department of Family Medicine, Yeom Chang Hwan Hospital, Seoul, Korea.South Korea
- 文献类型
- 病例报告
- 期刊
- Korean journal of clinical oncology2024 Dec
- 原文标识
- PubMed 39778511 · DOI 10.14216/kjco.24012