肿瘤细胞治疗研究
英文原题：RNA-loaded nanoparticles for the treatment of hematological cancers.
RNA-loaded nanoparticles for the treatment of hematological cancers.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
血液系统恶性肿瘤包括一组影响血液、骨髓、淋巴结和脾脏的多种恶性肿瘤。
血液系统恶性肿瘤包括影响血液、骨髓、淋巴结和脾脏的多种恶性肿瘤。这些疾病由于其复杂的病因学和多样的临床表现而带来独特的挑战。尽管在理解和治疗血液系统恶性肿瘤方面取得了重大进展，但仍不断寻求创新的治疗方法以改善患者预后。本综述重点介绍RNA纳米颗粒（RNA-NPs）在血液系统癌症治疗中的应用。我们深入讨论了涉及RNA-NPs用于成人患者的体外和临床前研究，以及RNA-NPs在儿童血液系统癌症中的应用。本综述还涉及正在进行的涉及RNA-NPs的临床试验，并探讨了由RNA-NPs工程化的CAR-T 疗法这一新兴领域。最后，我们讨论了将RNA-NP研究转化为临床仍面临的挑战。
Hematological cancers encompass a diverse group of malignancies affecting the blood, bone marrow, lymph nodes, and spleen. These disorders present unique challenges due to their complex etiology and varied clinical manifestations. Despite significant advancements in understanding and treating hematological malignancies, innovative therapeutic approaches are continually sought to enhance patient outcomes. This review highlights the application of RNA nanoparticles (RNA-NPs) in the treatment of hematological cancers. We delve into detailed discussions on in vitro and preclinical studies involving RNA-NPs for adult patients, as well as the application of RNA-NPs in pediatric hematological cancer. The review also addresses ongoing clinical trials involving RNA-NPs and explores the emerging field of CAR-T therapy engineered by RNA-NPs. Finally, we discuss the challenges still faced in translating RNA-NP research to clinics.
MEMBER ACCOUNT
登录成功会直接打开下一页。
