肿瘤细胞治疗研究
英文原题：Natural killer cells: a future star for immunotherapy of head and neck squamous cell carcinoma.
免疫成分与上皮之间的相互作用在头颈部鳞状细胞癌（HNSCC）的发生和进展中起着至关重要的作用。
免疫成分与上皮之间的相互作用在头颈部鳞状细胞癌（HNSCC）的发生和进展中起着至关重要的作用。自然杀伤（NK）细胞作为主要的肿瘤杀伤免疫细胞群体之一，在HNSCC免疫治疗中受到越来越多的关注。在本综述中，我们探讨了NK细胞与HNSCC之间相互作用的机制。癌细胞利用一系列免疫逃逸策略限制了NK细胞对HNSCC的浸润。克服这些限制可以充分发挥NK细胞的抗肿瘤潜力。我们还研究了基于NK细胞的免疫疗法的肿瘤杀伤效果、免疫治疗策略以及临床试验的新结果。值得注意的是，西妥昔单抗作为基于NK细胞免疫治疗的最重要组成部分，抑制表皮生长因子受体（EGFR）信号通路，并与NK细胞协同激活免疫系统，诱导先天效应功能并改善患者预后。此外，我们汇总了利用抗EGFR受体单克隆抗体药物改善患者预后的其他领域信息，以及治疗HNSCC的新型免疫治疗策略的潜在机制和预后。
The interplay between immune components and the epithelium plays a crucial role in the development and progression of head and neck squamous cell carcinoma (HNSCC). Natural killer (NK) cells, one of the main tumor-killing immune cell populations, have received increasing attention in HNSCC immunotherapy. In this review, we explore the mechanism underlying the interplay between NK cells and HNSCC. A series of immune evasion strategies utilized by cancer cells restrict HNSCC infiltration of NK cells. Overcoming these limitations can fully exploit the antineoplastic potential of NK cells. We also investigated the tumor-killing efficacy of NK cell-based immunotherapies, immunotherapeutic strategies, and new results from clinical trials. Notably, cetuximab, the most essential component of NK cell-based immunotherapy, inhibits the epidermal growth factor receptor (EGFR) signaling pathway and activates the immune system in conjunction with NK cells, inducing innate effector functions and improving patient prognosis. In addition, we compiled information on other areas for the improvement of patient prognosis using anti-EGFR receptor-based monoclonal antibody drugs and the underlying mechanisms and prognoses of new immunotherapeutic strategies for the treatment of HNSCC.
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