CELL INTELLIGENCE · 肿瘤细胞治疗研究

Teclistamab is a B-cell maturation antigen (BCMA)-directed bispecific antibody approved for the treatment of patients with triple-class exposed relapsed/refractory multiple myeloma (R/RMM). In the phase 1/2 MajesTEC-1 study, a cohort of patients who had prior BCMA-targeted therapy (antibody-drug conjugate [ADC] or chimeric antigen receptor T-cell [CAR-T] therapy) was enrolled to explore teclistamab in patients previously exposed to anti-BCMA treatment. At a median follow-up of 28. 0 months (range, 0. 7-31. 1), 40 patients with prior BCMA-targeted therapy had received subcutaneous 1. 5 mg/kg weekly teclistamab. The median prior lines of treatment was 6 (range, 3-14). Prior anti-BCMA therapy included ADC (n = 29), CAR-T (n = 15), or both (n = 4). The overall response rate was 52. 5%; 47. 5% of patients achieved very good partial response or better, and 30.

0% achieved complete response or better. The median duration of response was 14. 8 months, the median progression-free survival was 4. 5 months, and the median overall survival was 15. 5 months. The most common treatment-emergent adverse events (TEAEs) were neutropenia, infections, cytokine release syndrome, and anemia; cytopenias and infections were the most common grade 3 TEAEs. Infections occurred in 28 patients (70.

0%; maximum grade 3/4, n = 13 [32. 5%]; grade 5, n = 4 [10%]). Before starting teclistamab, baseline BCMA expression and immune characteristics were unaffected by prior anti-BCMA treatment. The MajesTEC-1 trial cohort C results demonstrate favorable efficacy and safety of teclistamab in patients with heavily pretreated R/RMM and prior anti-BCMA treatment. This trial was registered at www. ClinicalTrials. gov as #NCT03145181 and #NCT04557098.