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黑色素瘤辅助治疗和新辅助治疗的研究进展

英文原题:Advances in Adjuvant and Neoadjuvant Therapy for Melanoma.

查看英文原题

Advances in Adjuvant and Neoadjuvant Therapy for Melanoma.

PubMed 2024/07/26(内容时间) Hematol Oncol Clin North Am Q2 · IF 3.1(JCR 2025)

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中文摘要

黑色素瘤仍然是美国诊断的最常见癌症之一,但可切除疾病的治疗已取得重大进展。免疫检查点阻断(ICB)辅助治疗和BRAF/MEK抑制剂(BRAF/MEKi)靶向治疗现已成为可切除IIIB-IV期黑色素瘤的标准治疗。在本文中,作者讨论了与可切除黑色素瘤治疗相关的近期科学进展,包括ICB、BRAF/MEKi靶向治疗、溶瘤病毒、TIL(肿瘤浸润淋巴细胞)疗法和癌症疫苗。

展开英文摘要原文

Melanoma remains one of the most common cancers diagnosed in the United States, yet there have been substantial advancements in the treatment of resectable disease. Adjuvant therapy with immune checkpoint blockade (ICB) and targeted therapy with BRAF/MEK inhibitors (BRAF/MEKi) have now become standard of care for resectable stage IIIB-IV melanoma.

In this article, the authors discuss recent scientific developments pertinent to the treatment of resectable melanoma including ICB, targeted therapy with BRAF/MEKi, oncolytic viruses, tumor-infiltrating lymphocyte therapy, and cancer vaccines.

论文信息

作者
Sierra-Davidson K、Boland GM
第一作者单位
Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.United States
通讯作者单位
Department of Surgery, Massachusetts General Hospital, Boston, MA, USA. Electronic address: gmboland@mgh.harvard.edu.United States
文献类型
综述 · 非美国政府资助研究
期刊
Hematology/oncology clinics of North America2024 Oct
原文标识
PubMed 39060118 · DOI 10.1016/j.hoc.2024.05.007