通过靶向肿瘤相关巨噬细胞的嵌合受体工程化溶瘤病毒重振内源性抗肿瘤免疫
Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages.
英文原题:Advances in Adjuvant and Neoadjuvant Therapy for Melanoma.
Advances in Adjuvant and Neoadjuvant Therapy for Melanoma.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
黑色素瘤仍然是美国诊断的最常见癌症之一,但可切除疾病的治疗已取得重大进展。免疫检查点阻断(ICB)辅助治疗和BRAF/MEK抑制剂(BRAF/MEKi)靶向治疗现已成为可切除IIIB-IV期黑色素瘤的标准治疗。在本文中,作者讨论了与可切除黑色素瘤治疗相关的近期科学进展,包括ICB、BRAF/MEKi靶向治疗、溶瘤病毒、TIL(肿瘤浸润淋巴细胞)疗法和癌症疫苗。
Melanoma remains one of the most common cancers diagnosed in the United States, yet there have been substantial advancements in the treatment of resectable disease. Adjuvant therapy with immune checkpoint blockade (ICB) and targeted therapy with BRAF/MEK inhibitors (BRAF/MEKi) have now become standard of care for resectable stage IIIB-IV melanoma.
In this article, the authors discuss recent scientific developments pertinent to the treatment of resectable melanoma including ICB, targeted therapy with BRAF/MEKi, oncolytic viruses, tumor-infiltrating lymphocyte therapy, and cancer vaccines.
MEMBER ACCOUNT
登录成功会直接打开下一页。